Virology
Alternatively spliced soluble CARs inhibit coxsackievirus infection
Published in Blood Weekly, July 1st, 2004
"The coxsackie-adenovirus receptor (CAR) is a transmembrane receptor of the immunoglobulin superfamily whose expression is altered in myocardial and malignant diseases. Soluble isoforms of other adhesion molecules and cytokine receptors have been proven to have significant agonist and antagonist effects on their full-length receptors; however, little is known about soluble CAR receptors," investigators in the United States wrote.
"Using reverse transcription-PCR, we identified three CAR isoforms that lack the transmembrane domain and are the result of...
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Source: Blood Weekly (2004-07-01)
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