Virology
Molecular bases of Ad41 enteric tropism stem from its physicochemical properties
Published in Blood Weekly, July 1st, 2004
According to recent research published in the journal Virology, "Human enteric adenovirus Ad41 is associated with children gastroenteritis. To infect gastrointestinal cells, the invading virus must be acid-stable and resistant to inactivation by bile salts and proteases. In addition, it has to cross the mucus barrier before it infects mucosa cells."
"We show that Ad41 infectivity is not diminished by acid exposure, a condition limiting the infectivity of the respiratory Ad. This feature can be attributed to a large extent to the global basic charge...
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Source: Blood Weekly (2004-07-01)
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