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Stem-Cell Research

BM stem cells populate CNS into fully differentiated parenchymal microglia

Published in Blood Weekly, July 1st, 2004

Bone marrow stem cells populate the entire central nervous system into fully differentiated parenchymal microglia.

"Pluripotent stem cells can differentiate into a variety of cell types during tissue development and regeneration. However, it is still unclear whether bone marrow-derived stem cells can migrate across the blood-brain barrier in many regions of the central nervous system (CNS) and if these cells can readily differentiate into functional parenchymal microglia. We thus studied the differentiation fate of bone marrow stem cells upon immigration into the CNS," researchers in Canada report.

"To this end," wrote A.R. Simard and coworkers, "we...

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