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Tuberculosis Vaccine

Novel M. tuberculosis gene products to detect TB identified

Published in Blood Weekly, July 8th, 2004

Scientists have identified novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for the specific detection of human tuberculosis infection.

According to a study from England, "The tuberculin skin test for diagnosing Mycobacterium tuberculosis infection suffers from antigenic cross-reactivity of purified protein derivative with BCG, resulting in poor specificity in BCG-vaccinated populations. Comparative genomics has identified several genetic regions in M. tuberculosis and M. bovis that are deleted in M. bovis BCG. Proteins encoded in these regions will form the basis of new specific T-cell-based blood tests that do not...

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