Bacteriology
Lipoprotein NlpI involved in virulence of adherent invasive E. coli strain LF82
Published in Blood Weekly, July 8th, 2004
According to recent research published in the journal Infection and Immunity, "Escherichia coli strain LF82 recovered from a chronic lesion of a patient with Crohn's disease (CD) is able to adhere to and invade cultured intestinal epithelial cells and to replicate within macrophages. One mutant selected for its impaired ability to invade epithelial cells had an insertion of a Tn phoA transposon within the nlpI gene encoding the lipoprotein NIpI."
"A NIpI-negative isogenic mutant showed a 35-fold decrease in its ability to adhere to and a...
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Source: Blood Weekly (2004-07-08)
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