HIV/AIDS Research
KSHV-encoded LANA protein stabilizes beta-catenin by binding to GSK-3
Published in Blood Weekly, July 8th, 2004
"The Kapsosi's sarcoma-associated herpesvirus, KSHV, is associated with cancers that have increased incidence in patients who are also HIV positive or who have undergone organ transplantation. It has recently been observed that beta-catenin is overexpressed in two KSHV-associated cancers, Kaposi's sarcoma and primary effusion lymphoma," investigators in the United States report.
"Investigation of the underlying defect in beta-catenin regulation revealed that the KSHV-encoded LANA protein stabilizes beta-catenin by binding to...
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Source: Blood Weekly (2004-07-08)
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