Complementary & Alternative Medicine
Fas/FasL system is engaged at pharmacologically significant concentrations
Published in Blood Weekly, July 15th, 2004
According to published research from South Korea, "This research team found in previous studies that the ginseng saponin metabolite IH901 induces apoptosis in HepG2 cells via a mitochondrial-mediated pathway which resulted in the activation of caspase-9 and subsequently of caspase-3 and -8."
Based on these results, the involvement of the Fas/Fas ligand (FasL) death-receptor pathway, in IH901-induced apoptosis in HepG2 cells, was investigated. Levels of Fas and the Fas ligand (FasL) mRNA or protein were not increased by IH901," S.H. Oh and colleagues reported, "rather they...
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Source: Blood Weekly (2004-07-15)
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