Published in Blood Weekly, July 15th, 2004
"When P-catenin signalling is disturbed from mid-gestation onwards lineage commitment is profoundly altered in postnatal mouse epidermis. We have investigated whether adult epidermis has the capacity for P-catenin-induced lineage conversion without prior embryonic priming," scientists writing in the journal Development report.
"We fused N-terminally truncated, stabilized P-catenin to the ligand-binding domain of a mutant estrogen receptor (DeltaNbeta-cateninER). DeltaNbeta-cateninER was expressed in the epidermis of transgenic mice under the control of the...
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