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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . July 22nd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Hemodialysis - Diagnostic model helps detect cardiomegaly in dialysis patients

Infectious Disease - Cryptococcocis often causes death in liver transplant candidates

Obstetrics - Multiple vitamin deficiencies associated with anemia in last trimester

Stem-Cell Research - Novel model allows analysis of molecular pathogenesis of neuronal degeneration

Transfusion-Transmitted Virus - TT virus can replicate in bone marrow as well as in the liver

Adverse Drug Effects - Non-protein bound iron may be responsible for chemotherapy-induced toxicity

Allergy & Immunology - IgG4-switched B cells may undergo secondary switch to IgE in allergen exposure

Allergy & Immunology - Malassezia enhances natural killer cell-induced dendritic cell maturation

Allergy Medicine - Grass pollen-specific marker allergens molecularly characterized

Apoptosis - ARC protects against cell death through interaction with Bax

Assisted Reproduction - Anticoagulant heparin increases pregnancy rates

Bacterial Endotoxin - A synthetic peptide derived from BPI: aa 148-161 neutralizes endotoxin

Bacterial Infection -  C. pneumoniae-induced IFN-gamma dependent on 88-IFN-alpha beta-STAT1 signaling

Bacteriology -  L. pneumophila Philadelphia-1 magA expression developmentally regulated

Bacteriology -  Rickettsia prowazekii Madrid E strain proteome analyzed

Biomaterial - Silk fibroin nets form scaffolds that support microvessel development

Blood Supply - Red Cross in Central Oregon has only day's worth of some blood types on hand

Blood Volume Analyzer - LA County hospital to obtain BVA-100 for CCU

Chronic Lymphocytic Leukemia - Clinical trial to study Talabostat in advanced chronic lymphocytic leukemia

Chronic Lymphocytic Leukemia - FDA accepts HuMax-CD20 IND application for chronic lymphocytic leukemia study

Cord Blood Banking - Fifth BioArchive order placed by cord blood bank company in Taiwan

Coronavirus - SARS-CoV proteinase inhibitors may be developed from existing drugs

Cryopreservation - Chinese cord blood stem cell bank adopts BioArchive system

Diabetes - Islet-cell transplantation studies in primates to be conducted at UC Davis

Diagnostics - FDA approves new Reveal G2 Rapid HIV-1 antibody test

Endocrinology - Physical training may alter inflammatory factors/reduce delayed muscle soreness

Fungal Infection - Clinical factors predict fluconazole resistance/Candida blood infection survival

Gene Expression - BTLA negative regulator of activation and/or function of hemopoietic cell types

Gene Regulation - Ets gene PEA3 assists beta-catenin-Lef-1/c-Jun in OPN transcription regulation

Genomics - Polymorphic GATA site in IL-12R beta 2 promoter region affects transcription

Gynecologic Cancer - Alfa-epoietin can improve anemia in patients with gynecological cancer

HIV/AIDS - P24 tag useful tool for purifying and detecting recombinantly expressed scFvs

HIV/AIDS Research - Antigen-specific T cells migrate away from CXCR4-binding HIV-1 gp120

HIV/AIDS Research - Association not found between CCL3-L1 absence and HIV-1 infection susceptibility

HIV/AIDS Research - Furin processing likely mechanism for inactivating extracellular HIV-1 Tat

HIV/AIDS Research - HIV-1 RT and integrase proteins interact during viral replication

HIV/AIDS Research - HIV-1 immune response differs in exposed seronegative and seropositive partners

HIV/AIDS Research - Integrase plays important role during the RT step of the HIV life cycle

HIV/AIDS Research - Potential protective effect of HLA DQB1*06 alleles on course of HIV disease

HIV/AIDS Research - Structural/thermodynamic escape mechanism found from HIV-1 protease mutation

HIV/AIDS Research - Subtype D HIV-1 isolated from untreated individual highly resistant to NNRTIs

HIV/AIDS Research - TARTAR dimer therapeutic target for treatment of HIV-1 infection

HIV/AIDS Serology - Seronegative infection and AIDS is caused by HIV-1 A2 subsubtype

HIV/AIDS Therapy - ART efficacy after protease inhibitor failure better in NNRTI-naive patients

HIV/AIDS Therapy - Atazanavir is a new option for treatment of HIV infection

HIV/AIDS Therapy - Enfuvirtide safe and effective for adult and pediatric HIV-1 infection

HIV/AIDS Therapy - HAART effects survival and surrogate markers in vertically HIV-infected children

HIV/AIDS Therapy - Methadone plus HAART can be implemented with good results in HIV-infection

HIV/AIDS Transmission - HLA-DRB1 and -DQB1 variants associated with HIV-1 transmission events

HIV/AIDS Transmission - Substance abuse influences risky sex behavior

HIV/AIDS Treatment - CC-chemokine levels lack correlation with HIV-1 stage and response to treatment

HIV/AIDS-Related Conditions - Inflammatory and reactive arthropathies more prevalent in HIV infection

HIV/AIDS-Related Disease - CdCSH1p may have a role in adhesion of C. dubliniensis to fibronectin

HIV/AIDS-Related Disease - Chemokine-induced signaling pathways may mediate cell growth in Kaposi sarcoma

HIV/AIDS-Related Disease - Novel therapies developed for treatment of AIDS-related Kaposi sarcoma

HIV/AIDS-Related Disease - Prevalence of P. carinii mutations increased in the United States

HIV/AIDS-Related Disease - QTD PCR of oral-wash samples accurate and noninvasive for diagnosis of PCP

Hematology - Multiple myeloma patients require screening before receiving thalidomide

Hematology - Stimulated CD40 ligand stops mantle cell lymphoma proliferation

Hemotoxicity - HemoGenix launches HALO hemotoxicity test platform in Korea

Hepatitis Transmission - Viral hepatitis transmission in ambulatory health settings reviewed

Hepatitis Virus - Novel class of phosphonate nucleosides potent and selective anti-HBV agent

Herpesvirus - Post-translational HHV-6 IE1 protein modification by SUMO peptides characterized

Herpesvirus - Theta defensins protect cells from HSV by inhibiting viral adhesion/entry

Herpesvirus Research - Kaposi sarcoma-associated herpesvirus protease highly specific

Immunology - Antiviral cytokines induce granzyme B inhibitor/PI-9/SPI-6 hepatic expression

Immunology - B cells may trigger intestinal inflammation in inflammatory bowel disease

Immunology - CD43 regulation of T cell activation is through an intracellular mechanism

Immunology - CGRP down-regulates IL-2 and IFN-gamma and up-regulates IL-4 production

Immunology - DC maturation by AdV transduction enhances tumor Ag-specific T cell response

Immunology - I175E substitution converts Newcastle disease virus HN to an F-interactive form

Immunology - IFN-alpha priming results in a gain of proinflammatory function by IL-10

Immunology - IL-18 may affect B-cells through paracrine actions

Immunology - IL-8 complexes may be involved in lung inflammation pathogenesis

Immunology - Intensive sports training can decrease total NK cell cytotoxicity

Immunology - LC cysteine proteases limit cartilage derived CII-reactive T cell presentation

Immunology - Poly(I:C) may be one of the most appropriate agents to generate stable mature DC

Immunology - PrP-GFP expression models analyze activity of Prnp gene during prion infections

Immunology - Pro- and anti-inflammatory cytokines differentially regulated by PKC isoforms

Immunology - Restoration of NK cell development requires Fyn during early NK T cell ontogeny

Immunology - Toll-like receptor ligands directly promote activated CD4+ T cell survival

Immunology - Valpha24 NK T cells of CD4+ subset develop in the early fetal thymus

Immunology - p38 MAPK pathway critical for CD40L-mediated up-regulation of CD83

Infectious Disease - Brugia Rapid test detects filaria-specific IgG4 antibodies in endemic areas

Legal Issues - Justices order new trial over 1995 AIDS death

Leukemia - The HMG-I oncogene is overexpressed in human leukemia

Liver Regeneration - Beta-2-GPI is growth regulated and plays role as survival factor for hepatocytes

Medical Devices - Polyimide hollow-fiber oxygenator developed

Molecular Virology - JC virus genotyping offers new paradigm in the study of human populations

Neurology - N-acetylcysteine administration after focal cerebral ischemia protects brain

Neuroprotection - Cysteine prodrugs may be useful neuroprotectors in Parkinson disease treatment

Neuroscience - Brain emboli dissemination after captive bolt stunning can spread BSE in animal

Neuroscience - Cortical and subcortical GABA function may be compromised in schizophrenia

Non-Hodgkin Lymphoma - Researchers identify occupational exposures that increase NHL risk

Oncogenesis - Hepatitis C virus infection associates with the risk for Hodgkin disease

Oral Cancer - Relationship seen between oral carcinoma and exposure to tobacco smoke

Papillomavirus - All-trans retinoic acid suppresses transcription of HPV16

Parasitology -  S. mekongi discovery has implications for schistosomiasis-control strategies

Parasitology - Type I signal peptidase from Leishmania is a target of the immune response

Proteomics - SELDI technology aids analysis in kidney-transplantation rejection study

Renal Disease - Utility of testosterone replacement therapy in ESRD patients reviewed

Retroviral Infection - CD4+ regulatory T cells contribute to viral persistence

Retrovirology - Lentiviral and MLV based retroviral vectors for gene transfer elucidated

Retrovirology - Luciferase-based assay rapid and sensitive for detection of retrovirus entry

Sickle Cell Anemia - LifeShirt System used in study of sickle cell anemia and nocturnal hypoxia

Skin Grafts - FDA approves leeches as medical devices

Stem Cell Reseach - ABCG2 positive limbal epithelial cells putative corneal epithelial stem cells

Stem Cell Research - Mitochondrial and death receptor pathways in neural SC differentially regulated

Stem Cell Research - Poly(2-hydroxyethyl methacrylate)-based slabs used for embryonic SC support

Stem Cell Research - Self-renewing divisions of hematopoietic SC increased in absence of P18(INK4C)

Stem-Cell Research - A small modulatory dsRNA specifies fate of adult neural stem cells

Stem-Cell Research - Adenylyl cyclase seen to restrict clonal propagation of pluripotent stem cells

Stem-Cell Research - E2A-deficient hematopoietic progenitors are pluripotent after long-term culture

Stem-Cell Research - Genetically modified stem cells reverse neurodegenerative symptoms in mice

Stem-Cell Research - Glioma tropic neural stem cells consist of astrocytic precursors

Stem-Cell Research - HB-GAM inhibits proliferation and enhances differentiation of neural stem cells

Stem-Cell Research - Novel mechanism for regulating clonal propagation of ES cells is described

Stem-Cell Research - Scaffold hybridized with marrow stromal stem cells provides good osteoconduction

Stem-Cell Research - Sox-2 regulatory regions display activity in two types of multipotent stem cells

Stem-Cell Transplantation - EBMT Risk Score for CML patients receiving stem cell transplants is validated

Stem-Cell Transplantation - Heart allografts from donors lacking Flt3 ligand exhibit prolonged survival time

Stem-Cell Transplantation - RAG-1 is a suitable mouse model for mitochondrial DNA disease

Thrombosis - Heparin does not affect graft thrombosis incidence in pediatric renal allografts

Thrombosis - MATCH trial results: Adding aspirin to clopidogrel does not reduce stroke risk

Tissue Engineering - Fluoride substitutions of HAP viable for tissue replacement using stem cells

Tumor Suppression - Mechanism for T cell association with tumor regression elucidated

Virology - Amino acid variations in CTL epitopes can affect virus-specific CTL response

Virology - Differential cell killing by lymphomagenic MLV independent of p53 activation

West Nile Virus - West Nile virus control dependent on animal monitoring and disease research

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