Stem-Cell Research
Sox-2 regulatory regions display activity in two types of multipotent stem cells
Published in Blood Weekly, July 22nd, 2004
"The Sox-2 gene is expressed in embryonic stem (ES) cells and neural stem cells. Two transcription enhancer regions, Sox-2 regulatory region 1 (SRR1) and SRR2, were described previously based on their activities in ES cells. Here, we demonstrate that these regulatory regions also exert their activities in neural stem cells," scientists in Japan report.
"Moreover," S. Miyagi and colleagues said, "our data reveal that, as in ES cells, both SRR1 and SRR2 show their activities rather specifically in multipotent neural stem or progenitor cells but cease to function in...
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Source: Blood Weekly (2004-07-22)
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