Published in Blood Weekly, July 22nd, 2004
"Reverse transcriptase (RT) and integrase (IN) are two key catalytic enzymes encoded by all retroviruses. It has been shown that a specific interaction occurs between the human immunodeficiency virus type 1(HIV-1) RT and IN proteins (X. Wu, J. Virol. 73:2126-2135, 1999).
"We have "further examined this interaction to map the binding domains and to determine the effects of interaction on enzyme function. Using recombinant purified proteins, we have found that both a HIV-1 RT heterodimer (p66/p51 and its individual subunits, p51 and p66, are able to bind to HIV-1...
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