HIV/AIDS Research
HIV-1 RT and integrase proteins interact during viral replication
Published in Blood Weekly, July 22nd, 2004
"Reverse transcriptase (RT) and integrase (IN) are two key catalytic enzymes encoded by all retroviruses. It has been shown that a specific interaction occurs between the human immunodeficiency virus type 1(HIV-1) RT and IN proteins (X. Wu, J. Virol. 73:2126-2135, 1999).
"We have "further examined this interaction to map the binding domains and to determine the effects of interaction on enzyme function. Using recombinant purified proteins, we have found that both a HIV-1 RT heterodimer (p66/p51 and its individual subunits, p51 and p66, are able to bind to HIV-1...
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Source: Blood Weekly (2004-07-22)
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