Immunology
CGRP down-regulates IL-2 and IFN-gamma and up-regulates IL-4 production
Published in Blood Weekly, July 22nd, 2004
"The signal transduction of the cAMP/cAMP-dependent protein kinase [protein kinase A (PKA)] pathway through multiple receptors is critical for many processes in all cell types. In T cells, the engagement of both the TCR-CD3 complex and the CD28 co-stimulatory molecule also induces cAMP, and subsequently activates PKA," scientists in Japan report.
"It is believed that elevation of cAMP levels in T cells is inhibitory of IL-2 production and T cell proliferation. However, the function and detailed signal transduction mechanisms of the cAMP/PKA pathway in...
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Source: Blood Weekly (2004-07-22)
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