Blood Weekly

Immunology - Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells

Immunology - Subsets of CD25 T cells confer distinct suppressive properties upon CD4 cells

Infectious Disease - Epidemiology of coccidioidomycosis elucidated

Intracerebral Hemorrhage - Trial: NovoSeven effective in treatment of ICH

Leukemia - Complex chromosomes not always associated with rapid disease evolution in MDS

Leukemia - Researchers report on HOX expression's association with biologic subset of AML

Liver Disease - Macrophages, not stem cells, correct liver disease by fusion

Lupus Renal Disease - Articles address company's two candidates, Riquent and LJP 1082

Mergers & Acquisitions - AltaGen Biosciences acquired by biological products company

Mergers & Acquisitions - CRL enters collaboration to provide a global partner to pharma/biotech industry

Multiple Myeloma - Preclinical data on huN901-DM1 in multiple myeloma published in cancer journal

Mycobacteria - Appropriate therapy associated with efficacy in nontuberculous mycobacteria

Myelodysplastic Syndrome - Study determines best time for marrow transplant in patients with blood disorder

Myeloma - VEGF receptor inhibitor GW654652 discourages multiple myeloma metastasis

Neovascularization - R-cadherin antagonists counteract stem cell-derived pathological angiogenesis

Neuroscience - Developmental alcohol exposure disrupts circadian regulation of BDNF

Neurotoxin -  C. botulinum type B neurotoxin gene expression quantitated with RT-PCR assay

Obesity - Leptin and its receptor may promote immune dysfunction related to obesity/NHL

Obstetrics - Study supports enoxaparin use in pregnant women with thrombophilic disorder

Omega-3 Fatty Acids - Health-promoting Omega-3 fatty acids may be produced in bioengineered plants

Oncovirus - Heme oxygenase-1 is a therapeutic target for the treatment of Kaposi sarcoma

Ovarian Cancer - Dose-intense triplet chemotherapy with PBPC support investigated

Pancreatic Cancer - Ad/TRAIL-F/RGD may be potent therapeutic agent for pancreatic cancer

Parasitology - Catalytic mechanism of Trypanosoma cruzi trans-sialidase elucidated

Parasitology - Immune suppression increases risk of fatal strongyloidiasis in endemic areas

Preimplantation Genetic Diagnosis - Real-time PCR clinically useful for single-cell genotyping in blood diseases

Prescription Drugs - Newer heart drug is found to be no better than the old standby

Product Licensing - Spire receives catheter license payment from Bard

Quality Assurance - Laboratories and assays involved in multicenter studies of HCV need validation

Respiratory Virus - DNA flow-thru chip used for typing and subtyping of influenza viruses

Respiratory Virus - Heteroduplex mobility assay detects genetic variants of RSV subgroup A

Retrovirology - Progenipoietin-1 increases plasmacytoid/myeloid dendritic cells in SIV-infection

Retrovirus - Crystal structure of monomeric RT from MMLV revealed

Retrovirus Infection - HTLV-I infection may modify DPB pathogenesis via T cell activation

Sepsis - Utility of extracorporeal blood purification reviewed

Sickle Cell Disease - Collaboration to develop and commercialize sickle cell disease treatment

Stem Cell Research - Calcineurin moves stem cells towards differentiation

Stem Cell Research - Double labeling method measures cell turnover rates in colon

Stem Cell Research - Hoxb4 is essential for the normal proliferation of hematopoietic progenitors

Stem Cell Research - Stem cell transplantation reverses canine leukocyte adhesion deficiency

Stem Cell Research - Transplanted adult MSCs differentiate in regionally/temporally specific manner

Stem Cell Transplantation - Hematopoietic SC dose correlates with speed of immune reconstitution after SCT

Stem-Cell Research - 5azaD and TSA can be used to alter the fate of primitive HSCs/HPCs

Stem-Cell Research - AML1-ETO in hematopoietic stem cells preferentially enhances their maintenance

Stem-Cell Research - CD38 is functionally involved in CD83 expression and IL-12 induction

Stem-Cell Research - First evidence reported of human endometrial epithelial and stromal stem cells

Stem-Cell Research - GDNF promotes neuronal differentiation/dopaminergic development of neurospheres

Stem-Cell Research - GSM signals affect gene expression levels in tumor suppressor p53-deficient ESC

Stem-Cell Research - Growth factors, signalling pathway promote pancreatic gene expression

Stem-Cell Research - Jagged1-induced Notch signaling drives multiple myeloma cell proliferation

Stem-Cell Research - Jak 3 absence affects T-cell development

Stem-Cell Research - Mechanisms associated with IL-6-induced up-regulation of Jak3 elucidated

Stem-Cell Research - Pituitary gland affects self-renewing division of stem cells

Stem-Cell Research - Poly(alpha-hydroxy esters) support ES cell propagation in undifferentiated state

Stem-Cell Research - SCL required for normal function of short-term repopulating hematopoietic SCs

Stem-Cell Research - SSEA-1 epitope expression not essential for embryogenesis

Stem-Cell Research - Wnt signaling inhibits osteogenic differentiation of mesenchymal stem cells

Stem-Cell Transplantation - Acute gastrointestinal GVHD diagnosed frequently after allogeneic HCT

Stem-Cell Transplantation - CSP/MMF in URD HSCT patients acceptable toxicity but high rates of GVHD

Stem-Cell Transplantation - Chimeric CD19 Ab is option in post-transplant minimal residual B-lineage ALL

Stem-Cell Transplantation - Defibrotide given in addition to heparin may be efficient prophylaxis for VOD

Stem-Cell Transplantation - EBV viral load monitoring best used to enable prompt treatment of PTLDs

Stem-Cell Transplantation - HSC source should be considered based on data for individual ethnic populations

Stem-Cell Transplantation - HSCT survival from unrelated donors decreases with increased class I mismatches

Stem-Cell Transplantation - Proactive hNSCT prevents striatal neuron degeneration in Huntington disease

Stem-Cell Transplantation - Severe cGVHD characterized by high CD4⁺ cells relative to central memory cells

Stroke - Blood biomarkers for the early diagnosis of stroke identified

Stroke - Trial studies man-made blood clotting drug as treatment for hemorrhagic stroke

Thrombosis - CD39 regulatory mechanisms prevent thrombotic events in transgenic mice

Tissue Engineering - Novel aortic elastin and collagen scaffolds have tissue engineering potential

Tissue Engineering - Novel composite scaffold developed for load-bearing bone tissue engineering

Transfusion Medicine - Some patients will get blood transfusions with fewer white cells

Transplant Medicine - Immunosuppressive treatment doesn't appear to harm fetus of transplant patients

Transplant Medicine - Living related liver transplantation donors encounter short-term health effects

Vascular Disease - Origins of blood vessel cells discovered

Viral Genomics - Viremia ebbs and flows in chimpanzees with hepatitis C virus infections

Viral Infection - Viral meningoencephalitis diagnosis easier with modern laboratory techniques

Viral Pneumonia - Increased SP-A/defensin mRNA coincides with reduced viral load in pneumonia

Virology - Fractalkine may not be an absolute requirement for viral entry

Virology - IgM-capture ELISA offers early and rapid detection of enterovirus 71 infection

Wound Care - Adenosine A_2A receptor activation supports wound neovascularization