Stem-Cell Research
L3MBTL implications for pathogenesis of myeloid malignancy 20q deletions
Published in Blood Weekly, July 29th, 2004
"L3MBTL encodes a member of the Polycomb family of proteins, which, together with Trithorax group proteins, is responsible for the coordinated regulation of patterns of gene activity.
"Members of the Polycomb family also regulate self renewal of normal and malignant hematopoietic stem cells. L3MBTL lies in a region of chromosome 20, deletion of which is associated with myeloid malignancies and represents a good candidate for a 20q target gene," scientists in England report.
"However," said J. Li and colleagues, "mutations of L3MBTL have not...
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Source: Blood Weekly (2004-07-29)
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