Stem-Cell Research
Type I HBEC immortalization may be early step in breast cancer subset initiation
Published in Blood Weekly, July 29th, 2004
"The epithelial compartment of the human breast comprises two distinct cell types. Type I human breast epithelial cells (HBECs) are expressing luminal epithelial cell markers and stem cell characteristics, whereas Type II HBECs show basal epithelial cell phenotypes.
"When defined in terms of markers for normal cell lineages, most invasive breast cancer cells correspond to the phenotype of the common luminal epithelial cell," scientists in South Korea report.
"We had developed simian virus 40-immortalized cell lines from normal HBECs with luminal...
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Source: Blood Weekly (2004-07-29)
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