Blood Weekly
Susan Hasty, Publisher
Table of Contents . . . August 5th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Blood Weekly | Other Publications
Hematologic Disease - Hepatitis C virus associates with thrombocytopenia formation
Hematology - Single recombinant anti-RhD IgG prevents RhD immunization
Stem Cell Transplantation - Donor treatment with pegylated G-CSF promotes transplantation tolerance
Stem Cell Transplantation - IL-10/TNF alpha region haplotypes predict mortality after unrelated donor SCT
Stem Cell Transplantation - Steroid and cyclosporine A use are risk factors for bone loss following SCT
Acute Lymphoblastic Leukemia - Novel FLT3 inhibitors may be considered to treat hyperdiploid or relapsed ALL
Acute Myeloid Leukemia - FLT3 mutations in AML adversely associate with CR with intensive chemotherapy
Acute Myeloid Leukemia - Factors affecting good and poor CD34+ cell mobilization in AML determined
Acute Myeloid Leukemia - Timed sequential therapy for AML patients over 60 tolerated but unsatisfactory
Angiology - Pathway of platelet procoagulant activity is regulated by IQGAP1
Antipsychotic Therapy - Antipsychotics upregulate bcl-2 mRNA/protein in frontal cortex and hippocampus
Antiretroviral Therapy - Styrylquinolines do not interfere with HIV entry but act before integration
Antisense Technology - New methods ease the separation of antisense oligonucleotide in plasma
Apoptosis - P300 regulates p53-dependent apoptosis in colorectal cancer cells
Blood Banking - Southeastern Michigan Red Cross says blood banks out of type O, others types low
Blood Loss - Korean regulatory body approves blood plasma volume expander
Blood Testing - Galileo licensed for use in Japan and Canada
Bloom Syndrome - BLM and CAF-1 coordinate to promote survival in response to DNA damage
Bone Regeneration - PCL-TCP scaffolds seeded with osteoblasts sustains osteogenic expression
Bone Regeneration - PRDC is a potent BMP antagonist with a wide tissue expression pattern
Breast Cancer - Cancer therapeutics development company files IND for metastatic breast cancer
Breast Cancer - ER codon 594/HER2 codon 655 polymorphisms not associated with breast cancer risk
Breast Cancer - Increased serum folate levels associated with reduced breast cancer risk
Breast Cancer - Novel phosphorylation sites in HMGN1 protein from breast cancer cells identified
Breast Cancer - Tamoxifen metabolite R-isomer forms more DNA adducts in liver cells
Cancer Markers - Molecular markers useful to detect various stages of non-small-cell lung cancer
Carcinogens - Mechanism of benzene-induced leukemia elucidated
Cardiovascular Surgery - Endothelial progenitor cell mobilization encourages aortic repair
Cell Regulation - Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation
Chemotherapy - MAX2 reproducibly estimates average per patient risk for chemotherapy toxicity
Chemotherapy - siRNA against NF-kappaB p65 subunit enhances sensitivity to chemotherapeutics
Chronic Lymphocytic Leukemia - Alemtuzumab effective therapy for CLL with p53 mutations and deletions
Chronic Myelogenous Leukemia - IL-11 may improve thrombocytopenia associated with imatinib therapy in CML
Clinical Trial - Process uses riboflavin and light to reduce pathogens in donated blood
Collaborations - Agreement with Nycomed for development of Oxygent terminated
Complementary & Alternative Medicine - Herbs and spices have antimicrobial and chemopreventive properties
Coronary Heart Disease - Studies show Lovenox as an effective treatment of acute coronary syndromes
Cytomegalovirus - Real-time qPCR more sensitive than COBAS Amplicor for CMV DNA detection
DNA Repair - 53BP1 required for class switch recombination
Developmental Biology - Scientists discover key step in the development of nerve cells
Diagnostics - FDA grants waived status under CLIA for lipids test panel
Diagnostics - First predictive diagnostic to combat high sepsis mortality rates released
Diagnostics - Methylated DNA collected by tampons detects endometrial cancer
Drug Development - 1,4-Naphthoquinone derivatives have antiviral/antifungal/anticancer activities
Drug Toxicity - New product removes high-abundance proteins from mouse blood serum
Epstein Barr Virus - EBV viral load increases and reaches setpoint after HIV seroconversion
Fertility Preservation - Fertility preservation in females receiving cancer therapy is reviewed
Finance - Biopharmaceutical company announces going concern qualification
Finance - Medical instruments developer reports second-quarter sales higher than expected
Fungal Infection - Pneumocystis jirovecii identified in lung tissue sections from SIDS victims
Fungal Infection - Similar P. jirovecii genotypes found in different forms of infection
Gastric Cancer - Runx3 major growth regulator of gastric epithelial cells
Gene Expression - Promoter element location directs testis-specific Hst70/Hsp70.2 expression
Gene Expression - Role of TEL-AML1 fusion gene in molecular pathogenesis of ALL elucidated
Gene Probes - Four-color multiplex assays detect single nucleotide polymorphisms
Genome Analysis - Structure and function of chromosome 13q14 characterized
Genomics - Lentiviral vectors mediate CRE recombinase-inducible RNA interference
Genomics - MAGE-A1-expressing tumor cell 5' region less methylated than other parts of gene
Graft Versus Host Disease - DC stimulation of donor CD8+ T cells may be useful for prevention of GVHD
HIV Diagnosis - Clinical trials commence for HIV rapid test
HIV/AIDS Care - Kidney transplant in HIV infection plausible in era of HAART/immunosuppressives
HIV/AIDS Research - Chromatin structure affects HIV-1/ASV integration site selection opposite ways
HIV/AIDS Research - Differentially expressed genes in HIV-1-resistant cells analyzed by microarray
HIV/AIDS Research - Diketo acid integrase inhibitor resistance impairs HIV-1 replication/integration
HIV/AIDS Research - HIV-induced macrophage alterations play role in HIV encephalopathy pathogenesis
HIV/AIDS Research - Resistance mutations sustain or enhance CTL recognition of HIV-1 Pol epitopes
HIV/AIDS Research - Species-specific tropism determinants found in the HIV-1 capsid
HIV/AIDS Research - Tsg-101 protein has role in HIV Gag particle release
HIV/AIDS Therapy - NNRTI stereochemistry and regiochemistry profoundly affect anti-HIV activity
HIV/AIDS Therapy - Subcutaneous IL-2 therapy maintains CD4 cell increases in HIV-1 infection
HIV/AIDS-Related Disease - BCL-6 mutations seen in HIV-related pulmonary lymphoproliferative disorders
HIV/AIDS-Related Disease - HAART increases survival of patients with HIV-associated Hodgkin disease
Hematologic Malignancy - Notch-1 signaling mediates BMS influence on hematologic malignant cell growth
Hematology - Hemophagocytic syndrome can erupt after liver transplantation
Hematology - Novel human platelet septin SEPT8 is interaction partner of SEPT4
Hematopoietic Disease - Malignant hematopoietic disease from internal exposure to Pu-239 uncertain
Hepatitis C Virus - HCV screening for drug users/transfusion patients only is most cost-effective
Hepatitis C Virus - History of intravenous drug use strongest predictor for HIV/HCV coinfection
Hepatocellular Carcinoma - PIN1 overexpression/beta-catenin gene mutations distinct oncogenic events in HCC
Immunology - Sunscreen immune protection factors determined using dendritic cell suspensions
Leukemia - Gene profiles could improve acute leukemia diagnosis
Leukemia - Links Fore Leukemia raises $300,000 for The Leukemia & Lymphoma Society
Leukemogenesis - Mechanism of leukemogenesis described
Leukemogenesis - Molecular mechanisms of leukemogenesis by AML1/EVI-1 described
Malignant Mesothelioma - Novel chemotherapeutic agents promising for malignant mesothelioma
Multiple Myeloma - Phase I trial to investigate 17-AAG in multiple myeloma patients
Myeloma - Thalidomide's promising future in fighting cancer explored
Neuroscience - Coadministration of Pgp inhibitors improves docetaxel penetration into brain
Neuroscience - IL-1alpha and IL-6 protect neuronal SH-SY5Y cells from oxidative damage
Oncogene - p21-dependent cell cycle arrest guards against unrestricted cell proliferation
Oncogenes - P13K signaling essential for ABL oncogene-mediated B cell transformation
Organ Rejection - FDA grants permission for TAFA-93 clinical trial
Papillomavirus - HPV-11 early protein E6 dominant inducer of cytokine expression in RRP
Pediatric HIV/AIDS - Severe childhood malnutrition increases morbidity/mortality risk in HIV/AIDS
Personnel - Joseph R. Kletzel II named SVP of surgical products company
Pharmacogenetics - Pharmacogenetics can improve identification of high-risk ALL patients
Pneumococcus - Health groups reinstate recommendation for third dose of pediatric Prevnar
Prostate Cancer - New evidence shows Her-2/neu receptor correlates with prostate cancer risk
Retrovirus - HTLV-I dimerization initiation site forms hairpin loop
Rhabdomyosarcoma - Novel t(2;20)(Q35;p12) seen in childhood RMS with embryonal histology
Skin Cancer - CDKN2A/ARF gene mutation insignificant risk of FMM or MM in cancer aggregates
Skin Cancer - Oxidative stress/antioxidant network provide rationale for skin cancer treatment
Stem Cell Research - Apoptosis has role in development of AGM HSC revealed by Bcl-2 overexpression
Stem Cell Research - ESC-derived CD34+CD38-precursors exhibit embryonic gene expression pattern
Stem Cell Research - Epigenic regulation of HSC level directly affects the mature progeny
Stem Cell Research - FGFs enriches embryonic liver cultures for hepatic progenitors
Stem Cell Research - Gutlike organ formed from mouse embryonic stem cells characterized
Stem Cell Research - Interleukin-6 is an in vivo growth factor for mesenchymal precursors
Stem Cell Research - MGDF potent growth factor for primitive hematopoietic progenitors in the fetus
Stem Cell Research - PF4 enhances normal/leukemic stem/progenitor cell adhesion to endothelial cells
Stem Cell Research - PU.1 determines self-renewal capacity of erythroid progenitor cells
Stem Cell Research - Reductions in linker histone levels are tolerated in developing spermatocytes
Stem Cell Research - TNF-alpha suppresses GVHR by inhibiting IFN-gamma-dependent donor type-1 immunity
Stem Cell Transplantation - ATG added to conditioning regimen improves outcome in unrelated donor SCT
Stem Cell Transplantation - CMV-specific CD4+ and CD8+ T-cell lines rapidly generated for SCT
Stem Cell Transplantation - Combined stratification of refractory anemia improves prognosis in SCT
Stem Cell Transplantation - Encephalopathy in pediatric patients after HSCT associated with poor prognosis
Stem Cell Transplantation - GVHD major predictive factor for response to donor lymphocyte infusions in MM
Stem Cell Transplantation - Infused autograft lymphocyte dose affects clinical outcome post-SCT in MM
Stem Cell Transplantation - Infused cell dose predictive of outcomes after unrelated cord blood transplant
Stem Cell Transplantation - Primary systemic amyloidosis patients have increased survival following PBSCT
Stroke - Forest Laboratories announces desmoteplase agreement
Thrombosis - Multielement intravascular ultrasound reduces enoxaparin efficacy
Transfusion Technology - Mayo contracts for donor and transfusion software installation
Transplant Medicine - Sequential therapy treats recurrent hepatitis C after liver transplantation
Transplant Medicine - Study sets best time for bone marrow transplant in patients with blood disorder
Transplant Medicine - Washington state authorizes liver transplants at medical center
Tumor Suppression - RUNX3 is a bona fide tumor suppressor of gastric cancers
Tumor Suppression - p300 and CBP are suppressors of hematological tumor formation
Tumor Suppressor Gene - Somatic inactivation of Nfl induces a progressive myeloproliferative disorder
Tumorigenesis - Brca1 and Chk2 have collaborative roles in tumorigenesis
West Nile Virus - NIAID expands WNV treatment trial
West Nile Virus - WNV vaccine shows 100% protection in animal study, company reports
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