Stem Cell Transplantation
Donor treatment with pegylated G-CSF promotes transplantation tolerance
Published in Blood Weekly, August 5th, 2004
"We investigated whether the protection from graft-versus-host disease (GVHD) afforded by donor treatment with granulocyte colony-stimulating factor (G-CSF) could be enhanced by dose escalation," scientists writing in the journal Blood report.
"Donor treatment with human G-CSIF prevented GVHD in the B6->B6D2F1 murine model in a dose-dependent fashion," wrote E.S. Morris and colleagues, "and murine G-CSF provided equivalent protection from GVHD at 10-fold lower doses. Donor pretreatment with a single dose of pegylated G-CSF (peg-G-CSF) prevented GVHD to a significantly...
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Source: Blood Weekly (2004-08-05)
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