Graft Versus Host Disease
DC stimulation of donor CD8+ T cells may be useful for prevention of GVHD
Published in Blood Weekly, August 5th, 2004
"Graft versus host disease (GVHD) is triggered by host antigen-presenting cells (APCs) that activate donor T cells to proliferate and differentiate, but which APC-activated donor T-cell subsets mediate GVHD versus beneficial antitumor effects is not known.
"Using a CD8+ T cell-dependent mouse model of human GVHD, we found that host dendritic cell (DC)-induced CD44hiCD8+ effector/ memory T cells were functionally defective in inducing GVHD, whereas CD44loCD8+ naive phenotype T cells were extremely potent GVHD inducers,"...
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Source: Blood Weekly (2004-08-05)
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