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HIV/AIDS Research

Tsg-101 protein has role in HIV Gag particle release

Published in Blood Weekly, August 5th, 2004

The Tsg-101 protein has a role in HIV Gag particle release.

According to recent research published in the Journal of Virology, "Human immunodeficiency virus type 1 particles form by budding at the surface of most cell types. In this process, a piece of the plasma membrane is modified into an enveloped virus particle. The process is driven by the internal viral protein Pr551(gag).

"We have studied how host proteins in the membrane are dealt with by Pr55(gag) during budding. Are they included in or excluded from the particle' The question was approached by measuring the relative concentrations of host and viral proteins in the envelope of...

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