Stem Cell Research

Plzf required in adult male germ cells for stem cell self-renewal

Published in Blood Weekly, August 12th, 2004

Plzf is required in adult male germ cells for stem cell self-renewal.

According to a study from the U.S., "Adult germline stem cells are capable of self-renewal, tissue regeneration and production of large numbers of differentiated progeny. We show here that the classical mouse mutant luxoid affects adult germline stem cell self-renewal."

"Young homozygous luxoid mutant mice produce limited numbers of normal spermatozoa and then progressively lose their germ line after birth. Transplantation studies showed that germ cells from mutant mice did not colonize recipient testes, suggesting that the defect is intrinsic to the stem cells," F.W. Buaas and...

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Source: Blood Weekly (2004-08-12)

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