Stem Cell Research
Hematopoietic stem cells convert into liver cells within days without fusion
Published in Blood Weekly, August 19th, 2004
"Both plasticity and cell fusion have been suggested to have a role in germ-layer switching.
"To understand the mechanisms underlying cell fate changes, we have examined a highly enriched population of hematopoietic stem cells (HSCs) in vitro or in vivo in response to injury for liver-specific phenotypic and functional changes," scientists in the United States report.
"Here we show that HSCs become liver cells when cocultured with injured liver separated by a barrier. Chromosomal analyses and tissue-specific gene and/or protein expression show that...
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Source: Blood Weekly (2004-08-19)
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