HIV/AIDS-Related Encephalitis
IL-16 expressed in lymphocytes and microglia in HIV-1 encephalitis
Published in Blood Weekly, August 19th, 2004
According to a study from the United States, "IL-16 is a natural ligand for the CD4 molecule and is known for its chemotactic and anti-HIV-1 activities.
"We determined IL-16 expression in human brain tissue with HIV-1 encephalitis by specific immunocytochemistry and showed that infiltrating lymphocytes and activated microglia express IL-16."
"IL-16 immunoreactivity was particularly pronounced in microglial nodules. In vitro," M.L. Zhao and coworkers reported, "human foetal microglia and not astrocytes produce IL-16, and HIV-1 infection up-regulates microglial...
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Source: Blood Weekly (2004-08-19)
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