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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . August 26th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Banking - Hemolysate-filled PEI/PU microcapsules potential red blood cell substitutes

Extracorporeal Detoxification - Large-bore catheter complications characterized

Hematology - Oxygen binding of hemoglobin conjugated to carboxylate dextran reported

Herpesvirus - HHV-8-specific antibodies detected in HSCT recipients by peptide-based EIA

Kaposi Sarcoma-Associated Herpesvirus - KSHV infection can predispose cells to malignant transformation

Allergy & Immunology - IL-9 increases cytokine expression in activated mast cells

Angiology - Membrane type 1-matrix metalloproteinase links hemostasis to angiogenesis

Antimicrobial Susceptibility - Antimicrobial occurrence and susceptibility determined in Sfax-Tunisia isolates

Antiretroviral Therapy - Antiretroviral emtricitabine (FTC) has low toxicity in HIV-infected patients

Antiretroviral Therapy - Efuvirtide should still be considered outside of its optimal parameteters

Antiretroviral Therapy - Foscarnet-NNRTI conjugates potent activity against foscarnet-resistant HIV-1

Antiretroviral Therapy - Peptides isolated from tropical plants inhibit HIV-1 cytopathic effects

Antiretroviral Therapy - Peptides that bind to potent HIV-inactivating protein cyanovirin-N characterized

Antiretroviral Therapy - Rapeseed protein hydrolysates new source of HIV protease inhibitors

Antiretroviral Therapy - Ritonavir/ritonavir-boosted saquinavir does not effect saquinavir action

Antiretroviral Therapy - beta-D-3'-fluoro-2',3'-unsaturated nucleosides active against HIV

Antiviral Therapy - Novel bicyclic sugar modified nucleosides do not show antiviral activity

Bacterial Infection - Methicillin-resistant S. aureus infections are epidemic in injection drug users

Bacterial Infection - Toxic shock-like syndrome due to group C streptococcus is fatal

Bovine Spongiform Encephalopathy - Human mad cow infection may be more widespread than previously thought

Breast Cancer - Synthetic polypeptide against CXCR4 inhibits breast cancer metastasis

Business Update - Blood products group predicts big profit jump for year to June 30

Business Update - Living-tissue company pursuing medical device research grant

Cancer Therapy - Proteasome inhibitors encouraging as anticancer drugs

Candida Infection - Length of intensive care independent risk factor for Candida infection

Collaborations - Agreement signed with Asian partner for Intercept blood system for platelets

Collaborations - NSCC enters stem-cell agreement

Complementary & Alternative Medicine - Essential oils from coniferous trees are antibacterial and antifungal

Congenital Disease - Lentiviral-mediated gene therapy corrects lysosomal storage disease in mice

Coronavirus - Sensitive/specific EIA detects nucleocapsid antigen in sera from SARS patients

Coxsackievirus - Coxsackievirus B3-caused apoptosis is via VP2 and Siva protein interactions

Detection - Real-time PCR-based assay quantifies bacterial RNA in the environment

DiGeorge Syndrome - Babies with fatal genetic disorder saved by immune supression, thymus transplant

Diagnostics - ELISA for IgG against C. pneumoniae similar to microimmunofluorescence

Diagnostics - Novel assay detects/risk assesses food-borne thermotolerant campylobacter

Diagnostics - Real-time PCR quantifies intestinal bacterial populations

Drug Development - Enrollment completed in clinical trial for Gaucher disease

Drug Development - Synthetic blood test results air at anesthesiology group's meeting

Endometrial Cancer - Estrogen receptor modulator regulates proteins in endometrial cancer cells

Enterobacter Infection -  E. Sakazakii is rare cause of neonatal septicemia or meningitis in VLBW infants

Epidemics - Spatial data from single time point useful in epidemic estimations

Finance - Blood processing systems manufacturer reports first quarter financial results

Finance - Immucor announces stock repurchase program

Funding - Society awards $9 million in grants for leukemia, lymphona, myeloma research

HIV/AIDS Assay - Modified HIV genotype assay increases limit of detection below 1000 copies/ml

HIV/AIDS Epidemiology - Higher viral load may explain HIV CRF02_AG dominance in Ghana

HIV/AIDS Research - CD4 expression allows infection of CD8 cells by HIV

HIV/AIDS Research - Cerebral synthesis of complement factors strongly upregulated in SIV infection

HIV/AIDS Research - HIV Tat protein prevents long-term potentiation in hippocampal CA1 region

HIV/AIDS Research - HIV replication occurs predominantly in Th1 cells

HIV/AIDS Research - HIV-1 subtype B mutant escapes detection in fourth-generation HIV immunoassay

HIV/AIDS Research - Indinavir is only HIV-1 proteinase inhibitor that inhibits HTLV-1 proteinase

HIV/AIDS Research - Novel CCR5 antagonists have anti-HIV activity

HIV/AIDS Research - Novel cyanobacterial protein MVL inhibits HIV-1 envelope-mediated cell fusion

HIV/AIDS Research - Primary T cell HIV infection determined by tunable T cell activation thresholds

HIV/AIDS Research - SAR and pyrrolidineacetic acid derivatives are potent HIV CCR5 antagonists

HIV/AIDS Research - UltraSensitive AMPLICOR HIV-1 MONITOR v1.5 more sensitive than v1.0 near cutoff

HIV/AIDS Transmission - HLA-B allele-sharing associated with accelerated HIV transmission

HIV/AIDS-Associated Dementia - HIV associated neurodegeneration requires p53 in neurons and microglia

HIV/AIDS-Associated Infection - Hospital-acquired candidemia still a severe complication in advanced AIDS

HIV/AIDS-Associated Infection - L-AmB effective as secondary prophylaxis for leishmaniasis in HIV infection

HIV/AIDS-Related Cancer - IL-8 gene promoter polymorphism associated with risk of AIDS-related KS

HIV/AIDS-Related Pneumonia - CD4 T-cell subsets depressed in acute stage of HIV-related S. pneumoniae

HTLV-I Infection - Low prevalence of HTLV-I does not support screening blood donors in Lebanon

Heart Transplantation - Artificial heart pump trial to begin in the U.K.

Helicobacter Pylori - Basophils infiltrate human gastric mucosa at sites of H. pylori infection

Hematology - CXCR4 overexpression benefits repopulating CD34+ progenitors

Hematology - Scientists study older sickle cell patients in the United States

Hemodialysis - Tube model facilitates assessment of central venous catheter performance

Hemodialysis - Ulnar-basilic fistula access safe and effective

Hepatitis - High response rates achieved for treatment of hepatitis C and HIV

Hepatitis C Virus Transmission - Intravenous drug users inject less safely in prison than outside of prison

Herpesvirus Infection - KS associated with high pretransplant prevalence of HHV-8 among Africans

Immunology - Data: Human embryonic stem cells possess unique immune properties

Immunology - Evidence suggests positive selection plays key role in lymphocyte pools

Immunology - Researchers pinpoint identity of early-stage T cells circulating in blood

Immunosuppression - Cyclosporine microemulsion and tacrolimus are comparable in graft recipients

Infectious Disease -  Triatoma dimidiata reinfestation occurs even after insecticide application

Infectious Disease - Brazilian TT virus isolate closely related to SEN virus-F

Infectious Disease - Rapid field test developed for detection of hantavirus antibodies

Influenza Strains - Cross-protection explains single influenza illness peaks in temperate climates

Influenza Virus - Compatibility convergence between H1/N2 components of two influenza A subtypes

Influenza Virus - Influenza A virus NP sequence variation associated with escape from CTLs

Influenza Virus - Sensitive RT-PCR detects influenza A virus and amantadine-resistant isolates

Influenza Virus Epidemiology - Harmonization methods used to make spatial predictions for influenza data

Ischemic Disease - Umbilical cord blood cells stimulate post-ischemia neovascularization

Lead Exposure - Health Department to test Grand Island children for lead poisoning

Leukemia - Outcome for acute lymphoblastic leukemia linked to gene expression patterns

Leukemia - Protein loss plays role in acute T-cell leukemia

Liver Transplantation - Late hepatic artery thrombosis has little impact on liver graft survival

Lung Cancer - PCR detects genetic abnormalities in lung cancer and respiratory patients

Malignant Mesothelioma - SV40 could favor the survival of potentially neoplastic cells

Multiple Myeloma - Hematological cancers reflect angiogenic heterogeneity

Neurodegeneration - VEGF and bone marrow transplantation treat newborn mice with enzyme deficiency

Non-Hodgkin Lymphoma - Analysis of alveolar B lymphocytes contributes to diagnosis of lymphoma

Oncogenesis - Mcl-1 gene knockdown stimulates lymphoma cell apoptosis

Oncology - Overexpressed PDZK1 correlates with multiple myeloma drug resistance

Pancreatic Cancer - TGF-beta expression may not have prognostic significance in pancreatic cancer

Panic Disorder - Gene polymorphism associated with panic disorder with agoraphobia

Papillomavirus - Human papillomavirus type 16 most prevalent variant in area of Central Brazil

Papillomavirus - Reflex HPV DNA testing not useful for cytologic diagnoses of LSIL or AGC-NOS

Pediatric Cancer - HCV-associated liver disease in young cancer survivors shadows adult illness

Pharmacology - Capillary electrophoresis measures ribavirin in human plasma and serum

Renal Disease - Lamivudine-resistant hepatitis B virus thrives in kidney graft recipients

Reproductive Biology - Roles suggested for annexin IV and V in plasma of pregnant and postpartum women

Retroviral Research - HTLV-1 budding requires both Nedd4 and Tsg101

Retrovirolgy - Fusion of first 54 amino acids of Vpu to Env results in virus maturation

Retrovirology - Full-length HTLV-I genome from MT-2 cells constructed via overlapping PCR

Risk Factor - Genes encoding toxins of diverse S. flexneri isolates identified

Salmonella - Frequency/polymorphism of S. enterica sopE isolates detected by PCR/sequencing

Skin Cancer - p53 mutations common in HPV type 38-positive non-melanoma skin cancers

Spinal Cord Regeneration - Novel techniques promote recovery from spinal cord injury

Stem Cell Research - Agreement renewed to supply technology for detecting tumor cells in blood

Stem Cell Research - Amyloid-beta peptide has positive and deleterious actions in neurogenesis

Stem Cell Research - Angiogenic cytokine supports erythropoiesis during stem cell development

Stem Cell Research - At single cell level ESC-derived neurons integrate into the host brain circuitry

Stem Cell Research - CD34- SCID-repopulating cells are functionally different from CD34+ SRCs

Stem Cell Research - Cell therapy using human embryonic stem cells has wide potential

Stem Cell Research - Chronic ethanol consumption transiently reduces neural stem cell proliferation

Stem Cell Research - Embryonic stem cells express a unique set of microRNAs

Stem Cell Research - Endothelial progenitor-derived cells retain immature characteristics

Stem Cell Research - HAPO acts on primitive cells of hematopoietic and endothelial cell lineages

Stem Cell Research - Human embryonic stem cell lines bear unique gene sets

Stem Cell Research - Mesenchymal stem cells persist after transplantation into neonatal mice

Stem Cell Research - Neural stem cells survive, migrate, differentiate in pre-clinical stroke study

Stem Cell Research - Neuronal cells can be specifically generated from bone marrow stromal cells

Stem Cell Research - New approach toward immortalization of hepatic progenitor cells suggested

Stem Cell Research - Repression of germ cell differentiation parallels germ line SC maintenance

Stem Cell Research - SiRNA lentiviral delivery allows for efficient and stable gene silencing in HSCs

Stem Cell Transplantation - ASCT not superior to standard chemotherapy in primary refractory Hodgkin disease

Stem Cell Transplantation - IL-2-incubated SC and IL-2 associated with rapidly reversible toxicity in NHL

Stem Cell Transplantation - Kidney organogenesis needs functional anastomosis for viable transplant

Tissue Engineering - Method promotes differentiation/long-term survival of embryonic cardiomyoctes

Tissue Engineering - Therapeutic cloning potentially limitless source of cells for tissue engineering

Transfusion Medicine - $12 million to improve blood safety in Africa awarded to Emory, AABB, Red Cross

Transplant Medicine - Exploiting natural tolerance may help transplantation reach its potential

Transplant Medicine - Octogenarian livers compromise the survival of HCV-positive graft recipients

Transplant Medicine - Transplant pioneers, patients celebrate 20 years of organ transplants

Trypanosomiasis - Genetic stability seen in natural clones of Trypanosoma brucei

Tumorigenesis - Anti-ischemia agent ranolazine promotes development of intestinal tumors

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