Antiretroviral Therapy

Peptides isolated from tropical plants inhibit HIV-1 cytopathic effects

Published in Blood Weekly, August 26th, 2004

Peptides isolated from tropical plants inhibit the cytopathic effects of HIV-1.

"Using a high throughput screen based on the interaction of the HIV-1 gp41 ectodomain with the virucidal protein cyanovirin-N (CV-N), we isolated two new peptides which inhibited the binding of CV-N to gp41 and which subsequently showed anti-HIV activity in a whole cell assay," scientists in the United States report.

"A 5-kDa (contrajervin) and 10 kDa (treculavirin) peptide were isolated from Dorstenia contrajerva and Treculia obovoidea, respectively.

"Treculavirin was composed of two subunits, each containing 50 amino acid residues,...

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Source: Blood Weekly (2004-08-26)

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