Hematology

Oxygen binding of hemoglobin conjugated to carboxylate dextran reported

Published in Blood Weekly, August 26th, 2004

Scientists report the oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran in a recent issue of Biochimica Et Biophysica Acta - General Subjects.

"Human hemoglobin (Hb) conjugated to benzene tetracarboxylate substituted dextran produces a polymeric Hb (Dex-BTC-Hb) with similar oxygen affinity to that of red blood cells (P₅₀ =28-29 mm Hg). Under physiological conditions, the oxygen affinity (P₅₀ ) of Dex-BTC-Hb is 26 mm Hg, while that of native purified human HbA₀ is 14 mm Hg, but it exhibits a slight reduction in cooperativity (n₅₀ ), Bohr effect, and lacks sensitivity to...

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Source: Blood Weekly (2004-08-26)

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