Published in Blood Weekly, August 26th, 2004
"Human hemoglobin (Hb) conjugated to benzene tetracarboxylate substituted dextran produces a polymeric Hb (Dex-BTC-Hb) with similar oxygen affinity to that of red blood cells (P50 =28-29 mm Hg). Under physiological conditions, the oxygen affinity (P50 ) of Dex-BTC-Hb is 26 mm Hg, while that of native purified human HbA0 is 14 mm Hg, but it exhibits a slight reduction in cooperativity (n50 ), Bohr effect, and lacks sensitivity to...
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