Blood Weekly

Blood Banking - Cord blood company initiates lawsuits to protect patent rights

Blood Cancers - U.S. communities to raise money in September for blood cancer research

Blood Donations - Company introduces enhanced red cell collection technology

Hemophilia - Anti-idiotypic Ab neutralizes anti-C2 FVIII inhibitor

Transfusion Medicine - Blood donation may be a source of hepatitis E virus transmissions in Japan

Acute Myeloid Leukemia - AML-associated mutant inhibits differentiation of myeloid/erythroid stem cells

Adverse Drug Effects - Clopidogrel-associated autoimmune thrombocytopenic purpura reported

Antiretroviral Therapy - Efavirenz plasma levels reproducibly predictive of primary treatment failure

Antiretroviral Therapy - Novel benzodithiazines are nontoxic and have anti-HIV-1 integrase activity

Antiretroviral Therapy - Pancreatitis associated with didanosine plus tenofovirin in HIV infection

Antiretroviral Therapy - Ritonavir decreases nonrenal clearance of digoxin

Antiretroviral Therapy - Sustained benefit of HAART lost when prisoners return to community

Antitumor Agents - Levan polysaccharides have strong antitumor activity

Awards - U.S. NIH awards nearly $1.5 million for study of human bone precursor cells

Bacteriology - tetR real-time PCR detects and quantifies tetracycline-resistant bacteria

Biomedical Engineering - Researchers study the dependence of blood flow conductivity on flow velocity

Biotechnology - Pegylated polystyrene particles serve as a model system for artificial cells

Bone Repair - Stem cell gene therapy produces regenerative bone protein in healing mice

Business & Finance - Company reports $8.8M Q2 loss, provides clinical update

Business Update - Pharmaceutical company licenses compound from Millennium Pharmaceuticals

Business Update - Pittsburgh incubator signs Revivicor, Inc. as new tenant

Chronic Liver Disease - Liver-directed cell therapy is expected to augment organ shortages

Chronic Myelogenous Leukemia - Child with atypical CML treated successfully with imatinib mesylate

Clinical Trials - Biotech company updates phase 3 clinical trial of acute transfusion study

Cloning - Company introduces cloned cats born by new technique

Cold Agglutinin Disease - Rituximab safe and effective as CAD therapy

Coronavirus - Interferons effective in the treatment of severe acute respiratory syndrome

Coronavirus - SARS-CoV entry suppressed by peptides corresponding to HR on spike glycoprotein

Coronavirus - SARS-CoV follows the general fusion mechanism of class I viruses

Developmental Biology - New research focuses on developmental and stem cell biology

Diagnostics - Low viremia accounts for seronegative diagnoses in some hepatitis B carriers

Drug Development - Gene expression patterns in leukemia cells linked to treatment outcome

Embryogenesis - ETS transcription factor GABP alpha essential for early embryogenesis

Embryogenesis - pRb and p107 play a central role in regulating epidermal homeostasis

Embryonic Research - Embryos constructed through somatic cell nuclear transfer

Epstein-Barr Virus - P16(INK4A) status independent of EBV-induced cell proliferation and latency

Fungal Infection - New antifungal agents have potential role in prophylaxis

Gene Expression - HDAC inhibitors trigger apoptosis in HPV+ cells by inducing E2F-p73 pathway

Gene Therapy - Mobilization of antiretroviral SIV gene therapy vector is feasible

Genetic Risk - Polymorphism-197C/G in XBP1 may indicate a genetic risk for schizophrenia

Genomics - PRDM5 gene is silenced in human cancers and has growth-suppressive activities

Gliomatosis Peritonei - Gliomatosis peritonei is genetically unrelated to the associated teratoma

HIV/AIDS Coinfection - HSV-2 infection increases risk of HIV transmission

HIV/AIDS Gene Therapy - Lentivirus-based antisense vector inhibits HIV replication

HIV/AIDS Infection - Early HIV-1 diversity not restricted to certain risk groups/subtypes

HIV/AIDS Opportunistic Infection -  P. jiroveci polymorphisms suggest common infection source among disease type

HIV/AIDS Opportunistic Infection - Fungal pheromone receptor PCSTE3 from P. carinii cloned and characterized

HIV/AIDS Research - Abundant expression of granzyme A but not perforin in CD8+ cell granules in GALT

HIV/AIDS Research - Adoptive transfer of activated autologous CD4+ cells can augment immune system

HIV/AIDS Research - Brownian adhesive dynamics (BRAD) simulate receptor-mediated binding of viruses

HIV/AIDS Research - CD4+ and CD8+ T cell apoptosis inhibited by CXCR4 blockade in HIV-infected cells

HIV/AIDS Research - EE155 region has important role in down-regulation of CD4 by HIV-1 Nef protein

HIV/AIDS Research - Endosome disruption enhances functional nuclear delivery of Tat-fusion proteins

HIV/AIDS Research - Envelope glycoproteins not required for insertion of host ICAM-1 into HIV-1

HIV/AIDS Research - Fas-mediated apoptosis increased in PMNs from HIV-infected patients

HIV/AIDS Research - Functional SIV nef genes allow for efficient zoonotic infection in humans

HIV/AIDS Research - HIV Env-coreceptor interactions help mediate virus-cell/cell-cell fusion

HIV/AIDS Research - HIV-1 promoter contains a CATA box for optimal transcription and replication

HIV/AIDS Research - HIV-1-based vector used to develop mutants incapable of developing resistance

HIV/AIDS Research - HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-x_L

HIV/AIDS Research - IFN-gamma-induced inhibition of HIV replication mediated before virus entry

HIV/AIDS Research - Mast cells may serve as a viral reservoir for HIV-1

HIV/AIDS Research - Morphine prolongs survival of SIV-infected cells in early infection

HIV/AIDS Research - Multiple HIV-1 Nef functions contribute to efficient replication in macrophages

HIV/AIDS Research - N-linked glycosylation in CXCR4 N-terminus inhibits HIV-1 env gp binding

HIV/AIDS Research - Noninfectious X4 but not R5 HIV-1 inhibits lymphoid tissue antibody response

HIV/AIDS Research - Purifying selection masks mutational flexibility of HIV-1 reverse transcriptase

HIV/AIDS Research - Reduced glutathione and cysteine levels associated with HIV disease progression

HIV/AIDS Research - U937 cytokine secretion inhibited by HIV-1 gp120 C4-derived peptide constructs

HIV/AIDS Research - YMDD aspartates of p66 are required and sufficient for RT polymerase function