Leukemia

There is gene expression discordance within promyelocytic leukemia cells

Published in Blood Weekly, September 2nd, 2004

There is gene expression discordance within promyelocytic leukemia cells.

According to recent research from the United States, "acute promyelocytic leukemia (APL) is characterized by a translocation t(15:17) that fuses the retinoic acid receptor gene with the promyelocytic gene, which blocks differentiation to normal granulocytes. NB4 cells, derived from human acute promyelocytic leukemia, display this genotype and phenotype. All trans-retinoic acid (ATRA) induces differentiation of NB4 cell cultures in vitro and APL in vivo, although resistance to differentiation therapy frequently develops."

"To identify genes involved in differentiation, we...

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Source: Blood Weekly (2004-09-02)

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