Published in Blood Weekly, September 2nd, 2004
"The human immunodeficiency virus type 1 (HIV-1) Nef protein has been shown to accelerate viral growth kinetics in primary human T-lymphocytes and macrophages; however, the specific function(s) of Nef responsible for this phenotype in macrophages is unknown.
"To address this issue, mutants of a molecularly cloned macrophage-tropic isolate, HIV-1(SF162), were generated expressing single point mutations that abrogate the ability of Nef to interact with cellular kinases or mediate CD4 down-regulation," scientists in the United States report.
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