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Blood Weekly

Susan Hasty, Publisher
Table of Contents . . . September 9th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Products - BPAC recommends COBAS AmpliScreen HBV Test for donated blood

Creutzfeldt-Jakob Disease - Second probable case of CJD infection from blood transfusion

Hemophilia - Attitudes towards prenatal diagnosis and abortion compared in Iran and Italy

Stem Cell Transplantation - WT1 gene transcript assay predicts relapse in acute leukemia after SCT

Transfusion Medicine - Nucleic acid-amplification testing further safeguards nation's blood supply

AIDS/HIV Therapy - Systematic HAART for HIV patients with >500 T cell counts not supported by data

Acute Myeloid Leukemia - First patients enter pivotal phase II study of clofarabine

Alzheimer Disease - Assemblies of unmodified Abeta are proximate neurotoxin in Alzheimer disease

Amoebal Infection - Southeast Asia reports first case of B. mandrillaris meningoencephalitis

Angioplasty - Snake venom reveals clues about heart drug

Antibiotic Resistance - Resistance to third-generation cephalosporins in Enterobacteriaceae increased

Antiretroviral Therapy - Novel AZT and D4T derivatives show efficacy against HIV

Antiretroviral Therapy - Novel drug approaches minimize development of HIV-1 resistance to NNRTIs

Bacterial Genomics - S. dysenteriae 1 isolates derived from clone from single phage-integration event

Bacterial Genomics - Gaps in capacity of serum samples to neutralize S. aureus superantigens

Bacterial Infection - Enterobacter cloacae emerging as a common pathogen in neonatal units

Bioelectronics - Bioelectrical impedance is used in modeling of hemoglobin in dengue fever

Bioengineering - Delta LNGFR is a viable gene marker in engineered tissues

Biotechnology - Monitoring R-methadone plasma levels useful for adjusting drug dose

Biotechnology - microRNAs quantitated using a modified Invader assay

Breast Cancer - EGR3 involved in estrogen-signaling pathway in breast cancer

Bronchiolitis Obliterans - Bronchiolitis obliterans can limit survival after lung transplantation

Chlamydia - Chlamydia managed successfully with telephone follow-up management system

Chronic Liver Disease - Disease severity differs in North American and United Kingdom liver recipients

Chronic Lymphocytic Leukemia - CD40 hold potential for B-CLL therapy

Complementary & Alternative Medicine - Emodin inhibits tumor invasion through suppression of AP-1 and NF-kappa B

Complementary and Alternative Medicine - Certain dietary supplements pose a threat to liver transplant patients

Cytomegalovirus - CMV pp65 protein Ag recognized by CD4 cells induced with immunodominant peptides

Cytomegalovirus - CMV prophylaxis following BMT has changed the natural history of the disease

Cytomegalovirus - CMV viral proteins have adapted by functionally mimicking cellular genes

Cytomegalovirus - Cytokine flow cytometry analyzes T-cell responses to cytomegalovirus

Cytomegalovirus - Formation of effector memory CD4+ cells necessary for recovery of CMV infection

Cytomegalovirus - Gene transfer used to activate CMV specific T cells

Cytomegalovirus - Late CMV infection associated with SCT history of early CMV infection

Cytomegalovirus - New methods may improve management of late CMV infection following SCT

Diagnostics - Brucella Igm/IgG flow assays useful for diagnosis of brucellosis in endemic area

Diagnostics - False-negative syphilis test occurs in HIV infection due to prozone phenomenon

Diagnostics - Full lab evaluation of patients needed to correctly diagnose chronic diarrhea

Diagnostics - Phase I clinical trial initiated for EP-2104R

Diagnostics - Simple procedures preserve bone marrow mRNA and gene expression patterns

Disease Associations - Data linking B-cell non-Hodgkin lymphoma to hepatitis C is inconclusive

Drug Delivery - Formulation of oral heparin selected after successful clinical study

Drug Resistance - Mutations conferring drug resistance partially resensitize resistant HIV to AZT

Epstein-Barr Virus - EBNA-2 gene variant may play role in pathogenesis of oral hairy leukoplakia

Finance - Biopharmaceutical company announces financial results

Finance - Cancer company reports Q2 revenues of $212,000, down from same time last year

Finance - Cell-culture provider receives investment from Summit Partners

Finance - HemaCare reports profitable second quarter

Genetics - Study says genetic tests could make donated tissue safer

Genital Warts - Patient-applied home therapy attractive option for treatment of genital warts

HIV Diagnostics - Reveal Rapid HIV-1 Antibody Test No. 1 choice of U.S. hospitals, study shows

HIV/AIDS - Aerobic exercise dysfunction in HIV is potential link to physical disability

HIV/AIDS Diagnostics - Immuno-PCR for HIV-1 p24 antigen lowers HIV-1 viral load detection limits

HIV/AIDS Epidemiology - HIV infections increasing in vulnerable areas of Cambodia

HIV/AIDS Epidemiology - Incidence of sexually transmitted diseases increasing in Philippines

HIV/AIDS Infection - HIV infection increased 15% per year since 1997 in Taiwan

HIV/AIDS Infection - HIV prevalence increasing in Indonesia

HIV/AIDS Infection - New HIV infections increasing among young men in Hong Kong

HIV/AIDS Research - Available evidence base for HIV/AIDS control in India is suboptimal

HIV/AIDS Research - CXCR4 dimerization involved in SDF-1alpha- and gp120-induced signaling events

HIV/AIDS Research - Filgrastim activates replication of minor variants of HIV-1

HIV/AIDS Research - HIV protease inhibitors are inhibitors but not substrates of BCRP/ABCG2

HIV/AIDS Research - HIV-1 promotes quiescence in human neural progenitor cells

HIV/AIDS Research - Host factor Sam68 enhances HIV-1 RNA 3' end processing

HIV/AIDS Research - LNA/DNA chimeric oligomers mimic RNA aptamers targeted to HIV TAR RNA

HIV/AIDS Research - Several factors serve as determinants of sensitivity to HIV fusion inhibitors

HIV/AIDS Transmission - AIDS infection increasing via heterosexual transmission in Malaysia

HIV/AIDS Transmission - Needle exchange has helped addicts for 10 years

HIV/AIDS Transmission - Sex workers still a concern for HIV transmission in Singapore

HIV/AIDS-Associated Lymphoma - HAART improves outcome of HIV-associated plasmablastic lymphoma of oral cavity

HIV/AIDS-Opportunistic Infection - Pneumocystosis still major health problem for HIV-positive and -negative patients

Hantavirus Infection - High seroprevalence of hantavirus infection on Azuero peninsula of Panama

Hematology - Host environment guides endothelial progenitor cells and vascularization

Hemophilia - Acquired hemophilia masked by warfarin therapy described

Hepatitis B Virus - Low genetic diversity despite hyperendemicity of HBV genotype E in West Africa

Hepatitis C Virus - Drug users who are HCV-seronegative may be positive for RNA

Immunology - Close association between circulating cytokines and viral-induced malignancy

Immunosuppression - Rapid steroid withdrawal is appropriate for HCV-positive kidney recipients

Infectious Disease - Data suggest group C rotavirus infection transmitted from animals to human

Infectious Disease - Greater risk of systemic infection with epidemic L. monocytogenes strains

Influenza Outbreak - H2 influenza virus internal protein genes transmitted interregionally

Influenza Virus - NA and PB1 genes of H1N2 influenza A virus from pig is of human origin

Interferon - Four resistance factors identified in interferon inhibitory activity

Leishmania - Toll-like receptor 4 contributes to efficient control of Leishmania growth

Leukemia - Benzene emissions may quadruple risk of childhood leukemia

Leukemia - Leukemia stem cells replenish supply of cancerous cells, research shows

Liver Cancer - Hepatocellular carcinomas likely to increase in HIV/HBV coinfected patients

Liver Transplantation - Liver transplant recipients face graft rejection with interferon-based therapy

Malaria - Artesunate plus amodiaquine effective for treatment of uncomplicated malaria

Mergers & Acquisitions - Merger between Vitex and Panacos Pharmaceuticals endorsed

Multiple Myeloma - Research group launched to accelerate drug development for blood cancer

Mycobacterium - M. ulcerans-like infection in frogs may be potential human pathogen

Noscomial Infection - Molecular typing of A. flavus hospital outbreak show single contamination source

Personnel - Blood processing systems manufacturer announces new board members

Personnel - Cell-therapy company announces executive appointments

Personnel - Former Amgen VP, Brad Maroni, MD, joins stem cell company

Personnel - HEMOLINK maker announces appointment of Edward Lane to board

Pharmaceutical & Drug Development - Drug resistance mechanisms can reveal novel targets for antiretroviral agents

Pharmaceutical & Drug Development - Transporters play significant role in absorption and disposition of drugs

Prostate Cancer - Quantitative RAR beta 2 hypermethylation is a promising prostate cancer marker

Proteomics - Paramyxovirus SV5 fusion protein activation involves CT signaling to ectodomain

SARS - Dialysis patients with SARS often require longer hospitalization

SARS Coronavirus - Antibody response of SARS patients targets the viral nucleocapsid

Stem Cell Research - Activation of MAP kinase pathway by c-Kit is PI-3 kinase dependent in stem cells

Stem Cell Research - Adult mesenchymal stem cells used as a target for neoplastic transformation

Stem Cell Research - Cord blood banking company surpasses 100th unit for stem cell transplant

Stem Cell Research - Dendritic cell homeostasis may be disrupted at onset of GVHD

Stem Cell Research - Gene expression of T cell lineage development in thymus analyzed

Stem Cell Research - Msx2/necdin required for smooth muscle differentiation in mesoangioblast SCs

Stem Cell Research - Stem cells have a role in myocardial regeneration

Stem Cell Transplantation - Age 50 or older independent risk factor for HSCT treatment-related mortality

Stem Cell Transplantation - Cytogenetics independent predictor of relapse/treatment failure in AML

Stem Cell Transplantation - Data still inconclusive using stem cells to repair the heart

Stem Cell Transplantation - Diverse clinical applications using advantages of allogeneic PBL SCT

Stem Cell Transplantation - Efficacy of and indications for SCT for spinal cord repair still uncertain

Stem Cell Transplantation - Hepatocytes obtained after graft reduction may be used for liver transplant

Stem Cell Transplantation - High-dose chemotherapy with ASCT beneficial for bone and soft-tissue sarcomas

Stem Cell Transplantation - Mesenchymal SCs help repair kidney and improve function in acute renal failure

Stem Cell Transplantation - Method for widespread application of adoptive transfer of virus-specific T cells

Stem Cell Transplantation - Rare localized relapse in bone marrow of extremities after ASCT for ALL reported

Stroke - Tiny corkscrew clears blood clots

Tissue Engineering - Novel composite hydrogels promising for soft tissue engineering applications

Tonsillitis - "Hot" surgical techniques could increase postoperative hemorrhage

Transplant Medicine - Coalition America, INTERLINK contract to offer access to transplant network

Transplant Medicine - Interferon may lead to graft loss in liver transplant recipients

Transplant Medicine - Race affects the outcomes of patients awaiting liver transplantations

Vaccine Research - Government collecting blood from soldiers to create anthrax vaccine

Viral Genomics - Sapovirus isolates from outbreaks and acute gastroenteritis classified

West Nile Virus - West Nile virus outbreak in Sudan causes encephalitis in children

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