Proteomics
Paramyxovirus SV5 fusion protein activation involves CT signaling to ectodomain
Published in Blood Weekly, September 9th, 2004
"Many viruses have evolved fusion-mediating glycoproteins that couple the energy released from irreversible protein refolding to the work of membrane fusion. The viral fusion proteins require a triggering event to undergo a cascade of tightly regulated conformational changes.
"Different isolates of the paramyxovirus SV5 fusion (F) protein have either a short (20-residue) or long (42-residue) cytoplasmic tail (CT), and a long CT suppresses fusion activity in a sequence-specific manner," scientists writing in the journal Proceedings of the National...
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Source: Blood Weekly (2004-09-09)
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