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Complementary & Alternative Medicine
Emodin inhibits tumor invasion through suppression of AP-1 and NF-kappa B
September 9th, 2004
Emodin inhibits tumor invasion through suppression of activator protein- 1 and NF-kappa B. "3-Methyl-1,6,8-trihydroxyanthraquinone (emodin) is an active component from the rhizome of Rheum palmatum, a widely used traditional Chinese herb. In this study, we found that emodin significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced in vitro invasion of human cancer cells including HSC5 and MDA-MB-231 cells," scientists writing in the journal Biochemical Pharmacology report. "Matrix metalloproteinases (MMPs) are known to be associated with cancer invasion. Zymographic analysis showed that emodin suppressed TPA-induced MMP-9...
Source: Blood Weekly (2004-09-09)
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