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Cytomegalovirus
CMV pp65 protein Ag recognized by CD4 cells induced with immunodominant peptides
September 9th, 2004
The cytomegalovirus pp65 protein antigen is recognized by CD4 cells induced with immunodominant peptide pools. "Cellular immunity against cytomegalovirus (CMV) is essential for recovery from infection and control of viral latency. In immunocompromised hosts, this balance between CMV and cellular immunity is lost. Accordingly, restoration of the CD8 compartment specific for CMV is beneficial for immunocompromised patients," investigators in Italy report. "It is clear that CMV-specific CD4 cells provide helper functions facilitating long-term persistence of CD8 cells. Considering the dearth of data on CMV-specific T-helper cells, we investigated the...
Source: Blood Weekly (2004-09-09)
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