Drug Resistance
Mutations conferring drug resistance partially resensitize resistant HIV to AZT
Published in Blood Weekly, September 9th, 2004
According to recent research from France, "During zidovudine and stavudine treatment, HIV-1 selects several mutations (thymidine-associated mutations, TAMs) in the reverse transcriptase gene that confer high- and moderate-levels of resistance, respectively, to these nucleoside reverse transcriptase inhibitors (NRTIs)."
"The mechanism of the resistance provided by these mutations has long remained elusive. However, recent data showed that ATP-phosphorolysis, a reaction analogous to pyrophosphorolysis (the reverse of the nucleotide incorporation reaction) in which...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Blood Weekly
Source: Blood Weekly (2004-09-09)
More Articles from Blood Weekly
- Blood Products
BPAC recommends COBAS AmpliScreen HBV Test for donated blood - Creutzfeldt-Jakob Disease
Second probable case of CJD infection from blood transfusion - Hemophilia
Attitudes towards prenatal diagnosis and abortion compared in Iran and Italy - Transfusion Medicine
Nucleic acid-amplification testing further safeguards nation's blood supply - AIDS/HIV Therapy
Systematic HAART for HIV patients with >500 T cell counts not supported by data - Acute Myeloid Leukemia
First patients enter pivotal phase II study of clofarabine - More from this issue of Blood Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
