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Drug Resistance
Mutations conferring drug resistance partially resensitize resistant HIV to AZT
September 9th, 2004
Point mutations conferring drug resistance partially resensitize resistant HIV to AZT. According to recent research from France, "During zidovudine and stavudine treatment, HIV-1 selects several mutations (thymidine-associated mutations, TAMs) in the reverse transcriptase gene that confer high- and moderate-levels of resistance, respectively, to these nucleoside reverse transcriptase inhibitors (NRTIs)." "The mechanism of the resistance provided by these mutations has long remained elusive. However, recent data showed that ATP-phosphorolysis, a reaction analogous to pyrophosphorolysis (the reverse of the nucleotide incorporation reaction) in which...
Source: Blood Weekly (2004-09-09)
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