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HIV/AIDS Research
CXCR4 dimerization involved in SDF-1alpha- and gp120-induced signaling events
September 9th, 2004
CXCR4 dimerization is involved in SDF-1alpha- and gp120-induced signaling events. "Both the chemokine SDF-1alpha and the human immunodeficiency virus-1 (HIV-1) coat protein gp120 can bind to CXCR4 chemokine receptors but with different signaling consequences. "To understand the molecular basis for these differences, we tagged the rat CXCR4 receptor with enhanced cyan (ECFP) and yellow (EYFP) derivatives of the green fluorescent protein and investigated CXCR4 receptor dimerization in human embryonic kidney (HEK)-tsA201 cells using fluorescence resonance energy transfer (FRET)," wrote investigators in the United States. "Elevated...
Source: Blood Weekly (2004-09-09)
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