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HIV/AIDS Research
HIV-1 promotes quiescence in human neural progenitor cells
September 9th, 2004
HIV-1 promotes quiescence in human neural progenitor cells. "The exact mechanism by which human immunodeficiency virus type 1 (HIV-1) produces dementia remains obscure. We have recently found that chemokines can inhibit neural progenitor cell proliferation. We hypothesized that HIV-1 could also inhibit neural progenitor cell proliferation by chemokine receptor signaling," investigators in the United States report. "We found that HIV-1 coat proteins that used C-C chemokine receptor 3 or C-X-C chemokine receptor 4 as coreceptors inhibited proliferation of neural progenitor cells in isolated cultures, as well as in hippocampal slices. The cerebrospinal...
Source: Blood Weekly (2004-09-09)
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