Blood Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Blood Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Alzheimer Disease
Assemblies of unmodified Abeta are proximate neurotoxin in Alzheimer disease
September 9th, 2004
Small assemblies of unmodified amyloid beta-protein are a proximate neurotoxin in Alzheimer disease. "Pioneering work in the 1950s by Christian Anfinsen on the folding of ribonuclease has shown that the primary structure of a protein "encodes" all of the information necessary for a nascent polypeptide to fold into its native, physiologically active, three-dimensional conformation (for his classic review, see Science 1973;181:223). "In Alzheimer disease (AD), the amyloid beta-protein (Abeta) appears to play a seminal role in neuronal injury and death. Recent data have suggested that the proximate effectors of neurotoxicity are oligomeric Abeta...
Source: Blood Weekly (2004-09-09)
|
