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Coagulation Therapy

Traditional anticoagulants pose problems; Fondaparinux represents improvement

Published in Blood Weekly, September 16th, 2004

Traditional anticoagulants pose problems, but Fondaparinux - the first selective factor Xa inhibitor - represents an improvement

According to published research from the United States, "Warfarin and unfractionated heparin have been in clinical use for more than 50 years."

"Both are effective anticoagulants, but their use is associated with a number of impediments, including the need for intensive coagulation monitoring, wide variation in dose-response relationships, multiple drug interactions(in the case of warfarin), and serious immune-mediated thrombocytopenia (in the case of heparin)," wrote D. Hawkins of Mercer University in Atlanta,...

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