Stem Cell Research

CD8-deplted donor cell infusions effective for treatment of SCT relapse

Published in Blood Weekly, September 16th, 2004

CD8-deplted donor cell infusions are effective for the treatment of relapse after stem cell transplantation.

According to published research from the United States, "A CD8 murine monoclonal antibody-coated high-density microparticle (HDM) has been developed, which allows for the rapid depletion of CD8+ T cells from apheresis products by gravity sedimentation.

"We conducted a study to determine the efficacy and safety of CD8 depletion of donor lymphocyte infusions (DLI) to treat relapse after stem cell transplantation using the Eligix CD8-HDM Cell Separation System."

"Patients were targeted to receive 3x10⁷ CD4+ T...

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Source: Blood Weekly (2004-09-16)

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