HIV/AIDS-Associated Disease
Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy
Published in Blood Weekly, September 16th, 2004
"Infection of podocytes by HIV-1 induces unique changes in phenotype, which contribute to the pathogenesis of glomerular disease in HIV-associated nephropathy (HIVAN). The host genetic pathways altered by HIV-1 infection that are responsible for these phenotypic changes are largely unknown. researchers in the United States report.
"For identifying such pathways, representational difference analysis was performed comparing cDNA from HIV-1 transgenic podocytes with nontransgenic controls. In this way," L. Kaufman and colleagues wrote, "a gene named sidekick-1 (sdk-1) was cloned, a...
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Source: Blood Weekly (2004-09-16)
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