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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . September 23rd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Bacterial Detection - Novel assay improves detection rate of diarrhea-causing bacteria in stool

Blood Safety - U.S. Dept. of Defense funds Mirasol Pathogen Reduction Technology development

Blood Substitute - Blood substitute developer receives funding from Defense Appropriations Bill

Diagnostics - Serum procalcitonin more accurate than CRP as marker of bacterial infection

Stem Cell Transplantation - Neural stem cell transplants improve motor function in Huntington disease

Acute Myeloid Leukemia - Many questions about AML remain unanswered, and controversy continues

Angiology - Promising new anticoagulant offers fibrin-targeted factor Xa inhibition

Antiretroviral Therapy - HAART improves course of hepatitis C virus infection in HIV coinfected patients

Antiretroviral Therapy - Novel bioelectronic method detects HIV-1 drug resistance

Aspergillosis - Invasive aspergillosis before HSCT decreases patient survival

Aspergillus Terreus - Voriconazole may be better than a polyene for Aspergillus terreus infection

Bacterial Infection - Age/primary infection foci differs in invasive/noninvasive group A streptococci

Blood Banking - Lyophilization more successful with mononuclear cells than whole-cord blood

Blood Volume Analysis - Ohio independent diagnostic imaging center contracts for BVA-100

Breast Cancer - Estradiol-linked genotoxicants kill estrogen receptor-expressing cancer cells

Breast Cancer - Five or more circulating tumor cells may indicate more aggressive breast cancer

Breast Cancer - Liposome delivery of monesin overcomes problem of drug resistance

Cardiac Ischemia - Benidipine attenuates postischemic myocardial apoptosis

Cholera - Chironomid egg masses natural reservoir of V. cholerae non-O1 and non-O139

Chronic Hepatitis B - HBV-positive kidneys merit prudent use in HBV-infected transplant recipients

Chronic Hepatitis C - Interferon-alpha is a safe therapy for liver transplant patients

Clinical Trials - Phase 2a trials reopened as U.S. FDA, pharmaceutical company reach agreement

Collaborations - Biophysics company, Walter Reed agree to research biting insect problems

Collaborations - Blood center partners with UW to expand cord blood program

Collaborations - CuraGen inks collaboration with the NCI for clinical development of PXD101

Colorectal Cancer - qRT-PCR assay for CEA mRNA identifies disseminated tumor cells

Complementary & Alternative Medicine - Cannabinoids effective against cachexia-anorexia syndrome in HIV patients

Coronavirus - Structural basis proposed for coronavirus-mediated membrane fusion

Correctional Health - Organized healthcare delivery in Texas prison system improves health outcomes

Cryptosporidiosis - Cryptosporidiosis outbreak associated with a recreational swimming pool

Cytomegalovirus - Necrotizing enterocolitis with atypical features may signal infant CMV infection

Diagnostics - Nested PCR more sensitive than real-time PCR for detection of T. gondii

Diagnostics - Real-time PCR sensitive/specific for P. jiroveci from bronchoalveolar lavage

Endocrinology & Metabolism - Aerobic fitness associated with increased recovery of exercise-related hormones

Epidemiology - Infectious disease early-warning monitoring program free to Internet users

Epidemiology - Novel epidemic model presents a two-phase epidemic driven by diffusion

Escherichia Coli - Pathogenic E. coli in soil/vegetables contaminated with manure composts

Fungal Infection -  Candida dubliniensis isolated from non-HIV-infected patients in Kuwait

Fungal Therapy -  P. jiroveci DHPS polymorphisms confer resistance to sulfa drugs

Fungal Therapy - Fluconazole prophylaxis does not affect cortisol levels in critical illness

Fungal Therapy - Posaconazole is a new and potent antifungal medication

Genomics - Small interfering RNAs silence disease-related genes

HIV Coinfection - HIV-HTLV-I/II coinfection increases risk of clinical complications

HIV/AIDS Coinfection -  S. mansoni and HIV-coinfected patients mount specific immune response

HIV/AIDS Coinfection - Cytomegalovirus coinfection could affect HIV-1 disease progression in women

HIV/AIDS Gene Therapy - Novel target site for gene therapy may control/manage HIV-1 infection

HIV/AIDS Research - CpyA retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

HIV/AIDS Research - HIV hollow-fiber SCID model more cost effective than SCID/hu to evaluate therapy

HIV/AIDS Research - HIV replication rates should vary between cells with different lifespans

HIV/AIDS Research - HIV-1 -->Vpr sequence translocates bioactive macromolecules directly into nucleus

HIV/AIDS Research - Insect antiviral compound effective against HIV-1

HIV/AIDS Research - Novel approach analyzes immune response of HIV-infected individuals

HIV/AIDS Research - Novel component of innate immune system lethally hypermutates retroviruses

HIV/AIDS Research - Opiates enhance HIV-1 Tat cytotoxicity by direct actions on glial precursors

HIV/AIDS Research - Poly(acrylic acid) inhibits HIV-1 TAR RNA-Tat peptide interaction

HIV/AIDS Research - Progenitor cells may be a reservoir for HIV-1 in the brains of infected patients

HIV/AIDS Research - Replication-competent HIV-2 found in patients with undetectable viremia

HIV/AIDS Therapy - ART initiation during early infection results in lower residual HIV reservoirs

HIV/AIDS Therapy - Company reports preliminary data from Study 934, of HIV therapies

HIV/AIDS Therapy - Enfuvirtide long-term HIV therapy has few side effects

HIV/AIDS Therapy - HIV protease inhibitors directly interfere with insulin secretion

HIV/AIDS Therapy - Initiation of HAART being rethought amid toxicity/adherence concerns

HIV/AIDS Therapy - Lifetime control of HIV infection with HAART may be possible

HIV/AIDS Therapy - Mycophenolate mofetil and HAART delays viral load rebound in HIV infection

HIV/AIDS Therapy - Perirenal fat diameter early predictor of HAART-associated lipodystrophy

HIV/AIDS Therapy - Population model projects effect of HAART on evolution of HIV life history

HIV/AIDS Therapy - Social support/positive state of mind increases HIV treatment adherence

HIV/AIDS Treatment - Retinol assessment in HIV infection evaluates vitamin A deficiency in former IDU

HIV/AIDS-Associated Infection - ADA in CSF limited utility for tuberculous meningitis diagnosis in HIV infection

Hantavirus - Human and environmental factors caused hantavirus pulmonary syndrome outbreak

Heart Transplantation - Eighth implant of the VentrAssist "artificial heart" announced

Hematology - Factor VIII is retained in cellular intermediates during secretion

Hemorrhagic Fever - Ribavarin therapy effective against Crimean-Congo hemorrhagic fever

Hepatitis B Virus - Clevudine potent and tolerable in hepatitis B virus-infected patients

Hepatitis C Virus - Glycoprotein E2 has mechanistic features in common with class II fusion proteins

Hepatitis C Virus - HCV coinfection associated with higher risk of diabetes in HAART era

Hepatitis C Virus - Hepatitis C virus infection associated with increased risk of malignant lymphoma

Hepatitis C Virus - Peginterferon and ribavirin safe/effective in HCV-infected methadone patients

Immunology - Cytokine mutations associate with recurrent HCV after liver transplantation

Immunology - Novel method allows for selective adsorption of CD4+ T cells

Infectious Disease - Children at greatest risk of infection by enteric pathogens

Lung Transplantation - Pharma company granted Orphan Medicial designation for inhaled cyclosporine

Lymphoma - Analysis of gene expression in lymphoid cells can determine cancer

Lypodystrophy - PI substitution with abacavir in severe lipodystrophy markedly reduces lipolysis

Male Infertility - Teratocarcinoma-derived germ cells used to elucidate male infertility

Medical Devices - BioArchive system chosen for the new M.D. Anderson Cord Blood Stem Cell Bank

Medical Devices - Instruments company establishes award for advancements in organ preservation

Mergers & Acquisitions - Chiron acquires vCJD-focused company

Microbicides - HIV topical microbicides entering clinical trials should be reevaluated

Microbicides - PSC-RANTES blocks R5 HIV infection in immature Langerhans cells

Multiple Myeloma - Myeloma Institute at UAMS receives nearly $18 million grant from NCI

Myocardial Infarction - The optimal time to rebuild myocardium from BMDPC is within 2 weeks of MI

Obstetrics - Parvovirus B19 infection can cause dyserythropoietic anemia in pre-eclampsia

Oncogenesis - Hepatitis C virus infection may cause intrahepatic cholangiocarcinoma

Pain Medicine - Cannabinoids do not induce serious/relevant immunosuppression in humans

Parasitiology -  G. lamblia encystation dependent on novel transglutaminase activity

Patents - Cord-blood company licenses its patents to 80% of private cord-blood companies

Personnel - Dennis F. Marr named vice president of R&D for blood bank equipment company

Personnel - Drug development company names VP clinical development to lead Viprinex team

Personnel - Stem cell company retains Dr. Avraham Treves to consult on development efforts

Platelet Donation - Kansas couple plans trip to donate platelets at 35 blood donation centers

Pseudomonas - Transmissible P. aeruginosa in cystic fibrosis identified/characterized

SARS - Infectious disease consultants in U.S. question hospital preparedness for SARS

Salmonella - PCR primer pair based on 16S rDNA detects Salmonella serovars in food samples

Stem Cell Research - 17 Beta-estradiol enhances neuronal differentiation of embryonic stem cells

Stem Cell Research - 5-Azacytidine induces stem cells to differentiate into cardiomyocyte phenotype

Stem Cell Research - ABC transporter inhibitors enhance hematopoietic progenitor cell transduction

Stem Cell Research - Critical temporal requirement for RB genes during neuronal MSC differentiation

Stem Cell Research - Cryopreserved cord blood fractions alternative source of mesenchymal stem cells

Stem Cell Research - Dose rate at which lethal dose of TBR is delivered does not augment SC homing

Stem Cell Research - FgFr1 required for the proliferation of hippocampal progenitor cells

Stem Cell Research - Genes induced by GDNF overproduction of neuronal progenitor cells characterized

Stem Cell Research - Human cells for research and testing need to overcome longevity/culture problems

Stem Cell Research - Known and novel transcripts overexpressed in hematopoietic stem cells identified

Stem Cell Research - Neural stem cells in the subventricular zone resilient to hypoxia/ischemia

Stem Cell Research - Over 1700 human embryonic stem cell-material interactions characterized

Stem Cell Research - Public confused about role of adult stem cells, new NeoStem survey shows

Stem Cell Research - Serum-free media improve generation of embryonic stem cells

Stem Cell Research - Strategy proposed for breast stem cells to ignore mitogenic effects of estrogen

Stem Cell Transplantation - Allogeneic stem cell transplantation is safe in elderly patients

Syphilis - Increased syphilis testing coincided with public health interventions

Testicular Cancer - CIS/ITGCNU arises from developmentally arrested germ cells

Transplant Medicine - Cyclosporine A and PI interactions in liver transplantation can be managed

Transplant Medicine - Interleukin-4 gene transfer delays acute splenic allograft rejection in rats

Transplant Medicine - NOS isoforms have distinctive role during reperfusion following ischemia

Transplant Medicine - Obesity increases morbidity in kidney transplantation

Transplant Medicine - Pre-emptive antivirals aid living donor liver transplant recipients

Transplantation Medicine - Study finds heart transplant device reduces mortality in critically ill patients

Tuberculosis - Financial difficulties influence TB care-seeking behavior in rural China

Valve Prostheses - Study analyzes the closing behavior of mechanical aortic heart valve prostheses

Viral Evolution - Cross-reactive immunity leads to viral evolution, which limits extent of disease

West Nile Virus - Donated blood tests positive for West Nile virus

Wiskott-Aldrich Syndrome - Probing the surface of white blood cells enhances immune system medicine

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