Breast Cancer
Estradiol-linked genotoxicants kill estrogen receptor-expressing cancer cells
Published in Blood Weekly, September 23rd, 2004
According to a study from the United States, "A series of bifunctional compounds was prepared consisting of 17beta estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline."
"The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to the estrogen receptor," wrote U. Sharma and coauthors.
"Linker characteristics were pivotal determinants underlying the ability of the compounds to kill selectively breast cancer cells that express the...
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Source: Blood Weekly (2004-09-23)
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