Hematopoiesis
GATA-1 controls neurokinin-B synthesis in erythroid cells
Published in Blood Weekly, October 7th, 2004
According to a study from the United States, "The GATA family of transcription factors establishes genetic networks that control developmental processes including hematopoiesis, vasculogenesis, and cardiogenesis."
"We found that GATA-1 strongly activates transcription of the Tac-2 gene, which encodes proneurokinin-B, a precursor of neurokinin-B (NK-B). Neurokinins function through G protein-coupled transmembrane receptors to mediate diverse physiological responses including pain perception and the control of vascular tone.
"Whereas an elevated level of NK-B was implicated...
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Source: Blood Weekly (2004-10-07)
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