Blood Weekly
Susan Hasty, Publisher
Table of Contents . . . October 14th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Blood Weekly | Other Publications
Cord Blood Research - NF-kappaB activity differentially activated in cord blood
Hemodialysis - Disorders of mineral metabolism are associated with mortality in renal patients
Kidney Transplantation - Data presented on prevention of rejection after kidney transplantation
Lactobacillus - Components of L. helveticus fermented milk increase osteoblastic bone formation
Transfusion Medicine - Knowledge about infectious disease status guides our bioidentity
Anticoagulant Prophylaxis - Article reviews the epidemiology of venous thromboembolism
Anticoagulants - FDA committee wants more data to support approval of Exanta
Antioxidants - Antioxidant intervention protective against oxidative DNA damage
Bacterial Epidemiology - Group B Streptococcus prevalence determined among college roommates
Bacterial Resistance - MRSA isolated from the environment in a veterinary teaching hospital
Bacterial Sensitivity - P. aeruginosa isolates in Trinidad have relatively low drug resistance
Bacteriology - Bifidobacterial species induce Th2-driven immune response
Bone Grafting - Bone grafting company presents at technology conference
Brain Cancer - Company's lead cancer compound shown to cross blood-brain barrier
Breast Cancer - Breast cell proliferation related to steroid receptor expression
Breast Cancer - Cigarette smoke condensate induces transformation of normal breast cells
Breast Cancer - HDCT in chemosensitive and de novo metastatic breast cancer safe/well tolerated
Candida - Novel method characterizes Candida clusters in hospital outbreak
Cardiology - H2 O2 attenuates Ca2+ accumulation during reoxygenation
Cardiology - Study investigates the mechanism of myocardium protection
Cardiology - Unfractionated heparin will be replaced by better antithrombin agents
Cardiovascular Health - Review deals with the development of novel antiplatelet compounds.
Clinical Trials - Biopharmaceutical company gains early access to Dynepo oncology data
Creutzfeldt-Jakob Disease - vCJD epidemic estimated at 150-500 deaths if 11-15 year incubation period
Crohn Disease - Adolescents with Crohn disease have significantly reduced zinc absorption
Cytomegalovirus - Attenuated poxviruses elicit clinically relevant CMV-specific T cells
Cytomegalovirus - Cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer
Deep Vein Thrombosis - Advocacy group supports release of updated guidelines for the prevention of DVT
Deep Vein Thrombosis - High prevalence of thrombophilic defects in spontaneous and effort-related UEDVT
Diabetes - Company collaborates with JDRF to develop clinically useful hES cells
Diagnostics - Survivin measured by RT-PCR is biomarker in adult T-cell and acute leukemias
Drug Development - KD Trust backs research to find a cure for hemophilia
Enterobacter - ESBL-producing Enterobacteriaceae from a mix of strains spread in ICU
Escherichia Coli - pchABC genes necessary for full virulence of pathogenic/hemorrhagic E. coli
Facilities - Tissue-engineering company opens new facility
Feline Virus Infection - Viral infection outbreaks seen in cats in Wroclaw city area in Poland
Finance - Cardio-focused company announces fiscal 2004 financial results
Finance - Company raises $7M from sale of common stock
Finance - Cord blood banking company announces fourth quarter and year-end results
Finance - Targeted renal therapy company completes $5.6 million series C financing
Gene Targeting - Novel transgenic mouse used to evaluate NF-kappaB-induced transcription
HIV/AIDS Detection - Confocal microscopy used to detect and quantitate HIV-1 particles
HIV/AIDS Drug Resistance - Only HR-1 sequencing necessary to characterize T-20 resistance in HIV infection
HIV/AIDS Epidemiology - HIV-1 subtypes unchanged among heterosexuals in England and Wales from 1997-2000
HIV/AIDS Epidemiology - Primary HIV-1 drug resistance is low in Brazil
HIV/AIDS Healthcare - HIV/AIDS healthcare infrastructure helps decrease risk of drug resistance
HIV/AIDS Research - APOBEC3F is suppressed by HIV-1 and HIV-2 Vif proteins
HIV/AIDS Research - Antiretroviral host factor APOBEC3G targets specific virus species
HIV/AIDS Research - Decreased T-cell proliferation is central in CD4 cell expansions induced by IL-2
HIV/AIDS Research - HIV Gag self-association is not significantly influence by the P2 domain
HIV/AIDS Research - HIV-1 Gag assembles to a capsid through the formation of the 60 S multimer
HIV/AIDS Research - HIV-1 Nef equips dendritic cells to reduce survival and function of CD8 cells
HIV/AIDS Research - Human cytidine deaminase APOBEC3G is a broad antiviral enzyme
HIV/AIDS Research - Impaired cytokine production may contribute to OI in patients with CD4 recovery
HIV/AIDS Research - Monocyte behavior in HIV-1 influenced by FNf and protease/antiprotease ratio
HIV/AIDS Research - Monocytes and CD4+ cell compartmentalization of HIV-1 occur in late infection
HIV/AIDS Research - NRTIs have different effects on resting cells infected with HIV
HIV/AIDS Research - Prostate is a reservoir for HIV-1
HIV/AIDS Research - Residual granulocytes likely source of alpha-defensins released into CD8 culture
HIV/AIDS Research - TRIM5alpha important natural barrier to cross-species retrovirus transmission
HIV/AIDS Therapy - Antifungal peptides inhibit HIV-1 reverse transcriptase
HIV/AIDS Therapy - DCP analogues are potent anti-HIV agents
HIV/AIDS Therapy - Guidelines detail provision of adherence support to individuals receiving HAART
HIV/AIDS Therapy - HIV salvage therapy safe and effective in patients with >200 CD4+ cell counts
HIV/AIDS Therapy - No clinically significant drug interactions observed with tenofovir DF
HIV/AIDS Therapy - Novel technique monitors safety/efficacy of HIV therapy
HIV/AIDS Therapy - RNA aptamers promising as anti-HIV therapeutic tool
HIV/AIDS Therapy - Serum-free IC50 values determined for lopinavir and ritonavir
HIV/AIDS Therapy - Single mutations at HR1 env region result in loss of susceptibility to ENF
HIV/AIDS Therapy - Stereochemistry and regiochemistry of NNRTI profoundly affects anti-HIV activity
HIV/AIDS-Associated Disease - HIV-1 Tat increases adhesion of monocytes and T-cells to the endothelium
HIV/AIDS-Associated Tuberculosis - TB control/HIV care failures may contribute to continuing HIV-associated TB
HIV/AIDS-Related Drug Resistance - Novel method detects drug resistance of M-tropic and T-tropic HIV isolates
HIV/AIDS-Related Immunology - ILT2 expression may interfere with CD8 cell function by suppressing IFN-gamma
HIV/AIDS-Related Lipoatrophy - No change in mtDNA copy numbers in PBMCs in patients switched to abacavir
Heart Transplantation - Artificial heart pilot trial enrolment completion announced
Hematology - B-lineage specific lentiviral vectors offer controlled transgene expression
Hematology - VEGF receptors collaborate in the differentiation of bone marrow progenitors
Hematopoiesis - B-cell linker protein is essential for PLC-gamma2-induced Ca2+ influx
Hepatitis C Virus - Liver fibrosis predicts pegIFN/ribavirin outcome in HCV coinfection
Hepatitis C Virus Infection - Non-injecting sexual partners of HCV-infected persons at high risk for infection
Hepatitis C Virus Research - Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosornal degradation
Herpesvirus - New HSV antiviral drugs developed to counteract problems of current therapies
Human Herpesvirus - IFN-alpha and phosphonoformic acid inhibit HHV-8 infection and replication
Human Immunodeficiency Virus - Targeting of HIV-1 RNA-DNA hybrid structures potential strategy for therapy
Hypercholesterolemia - Atorvastatin treatment suppressed CD40L and P-selectin expression
Immunodeficiency Disorder - Flow cytometry confirms Wiskott-Aldrich syndrome in youth with thrombocytopenia
Immunology - Factor VIII DNA transfer stimulates anti-transgene antibodies in mice
Kaposi Sarcoma-Associated Herpesvirus - Recombinant KSHV with fluorescent protein enables study of lytic gene expression
Leukemia - Researchers demonstrate potential new approach to cancer drug therapy
Liver Transplantation - Researchers report on 18-year experience of liver transplantation
Lymphoma - Half of patients with aggressive non-Hodgkin lymphoma are undertreated
Lysophospholipids - Author raises questions about the role of lysophospholipids
Malaria - Malaria may be main cause of anemia in highland areas of Kenya
Malaria Therapy - Novel azole-based compounds have anti-malarial activity
Melanoma - c-Kit tyrosine kinase inhibitor STI571 could be used to treat uveal melanomas
Meningococcal Disease - Teacher dies of meningococcal disease
Mood Disorders - SERTPR variants are liability for lithium long-term efficacy in mood disorders
Multiple Myeloma - Multiple Myeloma Research Consortium awarded $1.5 million grant
Myeloproliferative Disease - Experimental drug shown to block mutant protein causing blood disease
Myocardial Infarction - Study evaluates the effect of melatonin on infarct size
Neurogenesis - Alproate promotes ERK pathway-dependent cortical neuronal growth/neurogenesis
Norovirus - Heteroduplex mobility assay identifies genomic diversity among noroviruses
Obesity - Weight reduction is accompanied by metabolic adjustments and weight regain
Personnel - Denise Fletcher joins DaVita
Personnel - Diagnostics testing company names executive to head medical business
Personnel - Leukemia expert joins pharmaceutical company's scientific advisory board
Product Licensing - Chiron grants nonexclusive license for HCV therapeutics
Proteomics - Novel protein distinguishes CD8 cells from other lymphocytes
Renal Failure - Biosurgical device company presented results of SynerGraft arteriovenous device
Respiratory Syncytial Virus - Genetic diversity of RSV isolated during an epidemic characterized
Retrovirus Research - SIV Vpr/Vpx kill bystander noninfected CD4+ cells by induction of apoptosis
Rotavirus - Group C rotavirus outbreak affected infants and children in Maizuru city
SARS Coronavirus - 3'-noncoding region based SARS-CoV RT-PCR assay detects SARS-CoV infections
SARS Coronavirus - Intestinal cell line permissive to SARS coronavirus
Sepsis - Updated guidelines address hemodynamic support of blood infection
Sickle Cell Disease - MX-1520, prodrug of vanillin, shows potent antisickling effect in study
Sickle Cell Disease - Vanilla may have a future in sickle cell treatment
Stem Cell Research - Ca2+ signaling explored in embryonic stem cells
Stem Cell Research - ESCs established from blastocysts differentiate into cardiomyoctes and neurons
Stem Cell Research - Early Trx/Ccl-2 expression favors increased survival potential of B cells
Stem Cell Research - Economic study demonstrates Proposition 71 benefits to California's economy
Stem Cell Research - Endothelial SCs create microvascular networks within tissue-engineered construct
Stem Cell Research - Hepatic-like cells from embryonic stem cells isolated and differentiated
Stem Cell Research - Multilineage inducible cells are ideal candidates for cellular therapies
Stem Cell Research - Odontoblasts induced from mesenchymal cells of murine dental papillae
Stem Cell Research - PDCs activate lymphoid-specific genetic programs irrespective of cellular origin
Stem Cell Research - Retinal progenitor cells isolated from post-mortem tissue
Stem Cell Research - Retroviral vector generates hematopoietic stem cell transduction in mice
Stem Cell Research - Stem cells have potential to replace degenerated articular condyles
Stem Cell Therapy - Embryonic SCs contribute to stable beneficial outcome in myocardial infarction
Stem Cell Transplantation - Autologous hematopoietic SCT promising for treatment of multiple sclerosis
Stem Cell Transplantation - IV busulfan-fludarabine effective/low toxicity for AML/MDS undergoing HSCT
Stem Cell Transplantation - Tolerance associated with CBT may depend on the state of host dendritic cells
Systemic Lupus Erythematosus - Disease activity is strongest risk factor for atherothrombosis in lupus
Thrombosis - Role of vitronectin in clot formation clarified
Thrombosis - Updated thrombosis guidelines offer recommendations
Transplant Medicine - Chance meeting leads to kidney donation
Tuberculosis - Bovine tuberculosis is a new threat to Africa
Tuberculosis - Brief exposure increases risk for Mycobacterium tuberculosis infection
Tula Virus - Tula virus strains from Poland closely related to TULV from elsewhere in Europe
Ventricular Assist Devices - Global begins for VentrAssist artificial heart
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