Myocardial Infarction

Study evaluates the effect of melatonin on infarct size

Published in Blood Weekly, October 14th, 2004

Melatonin does not prevent the protection of ischemic preconditioning in vivo despite its antioxidant effect against oxidative stress

"Free radicals are involved in the protective mechanism of preconditioning (PC), whereas antioxidant compounds abolish this benefit. Melatonin is a hormone with antioxidant properties. The aim of our study was to evaluate the effect of melatonin on infarct size in ischemic preconditioning in vivo," scientists in Greece report.

I. Andreadou and colleagues of the University of Athens described their approach, "We randomly divided 33 male rabbits into four groups and subjected them to 30 min of myocardial ischemia and 3 h...

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Source: Blood Weekly (2004-10-14)

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