HIV/AIDS Research
TRIM5alpha important natural barrier to cross-species retrovirus transmission
Published in Blood Weekly, October 14th, 2004
According to a study from the United States, "Mammalian cells express several factors that act in a cell-autonomous manner to inhibit retrovirus replication. Among these are the Friend virus susceptibility factor 1/lentivirus susceptibility factor 1/restriction factor 1 (Ref1) class of restriction factors, which block infection by targeting the capsids of diverse retroviruses."
"We show that lentivirus susceptibility factor 1 and Ref1 are species-specific variants of tripartite interaction motif 5alpha (TRIM5alpha), a cytoplasmic body component recently shown to...
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Source: Blood Weekly (2004-10-14)
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