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HIV/AIDS-Related Immunology

ILT2 expression may interfere with CD8 cell function by suppressing IFN-gamma

Published in Blood Weekly, October 14th, 2004

ILT2 expression may interfere with CD8 cell function by suppressing the production of IFN-gamma.

According to recent research published in the journal Immunology, "We investigated whether inhibitory natural killer cell receptor (iNKR) expression contributes to impaired antigen-specific cytotoxicity and interferon-gamma (IFN-gamma) production by CD8 T cells during chronic infection."

"iNKR immunoglobulin-like transcript-2 (ILT2/CD85j) is expressed on 40-55% of cytomegalovirus (CMV)-, Epstein-Barr virus (EBV)- and human immunodeficiency virus (HIV)-specific CD8 T cells in both healthy and HIV-infected donors. Other iNKRs (CD158a, b1, e1/e2, k,...

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