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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . October 28th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Cord Blood - Umbilical cord blood transplant after nonmyeloablative conditioning is promising

Hemophilia - Viruses bearing transgene generate coagulation factor in hemophilia A models

Liver Regeneration - Fluidized bed bioreactor has potential for extracorporeal liver supply

Non-Hodgkin Lymphoma - Allogeneic blood transfusion does not increase risk of non-Hodgkin lymphoma

Obstetrics - Diagnosis and management of twin-twin transfusion syndrome reviewed

Tissue Engineering - Novel scaffolds may be very useful for vascular tissue engineering

Acute Myelogenous Leukemia - Collaboration to develop immunostimulant, therapeutic vaccine approaches for AML

Adenovirus - Nosocomial infections in Japan caused by new adenovirus type 4 genomic variant

Allergy & Immunology -  S. aureus protein A induces airway inflammatory response by TNFRI activation

Angiology - Blood platelet components are important elements of angiogenesis

Antimicrobial Susceptibility - Real-time PCR detects A. phagocytophilum susceptibility to antimicrobials

Apoptosis - P63 and p73 not required for development and p53-dependent apoptosis of T cells

Atrophic Gastritis - Genetics/lifestyle influence protective effect for developing atrophic gastritis

Bacterial Resistance - Salmonellae acquire antimicrobial resistance independent of selection pressure

Biowarfare - Defensive measures elucidated for agents of biological warfare

Blood Collection - Twice as many red blood cells collected in one session at Stanford blood center

Bovine Spongiform Encephalopathy - Italy detects another case of mad cow disease

Brain Cancer - Temozolomide well tolerated in patients with primary CNS lymphomas

Breast Cancer - Genomic testing identifies chromosomal changes in sporadic breast cancer

Cardiovascular Disease - Drug discovery company reports acute peripheral arterial occlusion trial

Cardiovascular Surgery - Hemostatic activity in different PCIs compared

Chemotherapy - Imatinib mesylate inhibits T-cell growth and delayed-type hypersensitivity

Chemotherapy - PEI regimen active/well tolerated for sensitive relapsed small-cell lung cancer

Clinical Trials - Results in phase 2 clinical trial of claudication arterial drug announced

Congestive Heart Failure - Stem cell therapy improves heart function after heart attacks

Cytochrome P450 - CYP450 genetic polymorphism screening can optimize cancer treatment

Cytomegalovirus - Phase 1 clinical trial for cytomegalovirus gene encoded vaccine initiated

DNA Repair - Cadmium inhibits DNA mismatch repair

Decontamination - Surface sampling/QPCR analysis effective for decontamination strategy evaluation

Dermatology - EphA4 and twist are aberrantly expressed in Sezary syndrome

Diabetes Complications - Platelet activation in type 2 diabetes reviewed

Diagnostics - Blood group typing and antibody device development approved by FDA

Diagnostics - Correlations between magnesium status of neonates and mothers from blood/hair

Diagnostics - Methods for detection of Enterocytozoon bienuesi in stool specimens compared

Diagnostics - Novel PCR assay useful for rapid detection of emetic Bacillus cereus

Diagnostics - Quantitative real-time PCR useful for diagnosis of ocular toxoplasmosis

Diagnostics - Rapid real-time PCR detects/quantitates M. avium subspecies in contaminated milk

Diagnostics - Real-time PCR used to quantitate uncultured bacteria in central Baltic Sea

Diagnostics - Saliva samples offer potential alternative to blood testing

Diagnostics - Seminested PCR-enzyme immunoassay is favorable method for candidemia diagnosis

Diagnostics - UG52-UC53 and 292-222 primer pairs most appropriate for Echovirus detection

Drug Development - Brazilian researchers hope to turn rattlesnake poison into potent pain killer

Drug Development - Inhibitor design wraps packing defects in HIV-1 proteins

Drug Development - Novel HIV-1 integrase inhibitor has potent antiviral activity

Drug Importation - Governor tries to sell Illinoisans on drug import program

Emergency Preparedness - Emergency plans needed in event of bioterrorism or natural epidemic

Environmental Health - Officials warn gold panners in filthy Manila river

Environmental Health - Pennsylvania doctor criticizes state health department study

Finance - Pharma company increases Vidaza sales guidance

Food-Borne Illness -  E. coli O157:H7 uses different acid resistance systems

Foodborne Pathogens - Pathogenic enteric viruses persist in marinated mussels despite acid conditions

Foodborne Pathogens - Storage temperature affects ability of Streptococcus pyogenes to grow in food

Fundraising - Social awareness stamp for sickle cell disease introduced

Fungal Research - Gene essential for A. fumigatus growth but does not contribute to pathogenicity

Fungal Toxin - Fumonisins detected in herbal tea and medicinal plants in Turkey

Gastric Cancer - EBV-gastric carcinoma pathogenesis different in intestinal or diffuse EBV-GC

Gene Therapy - Break repair protein endo-exonuclease is a therapeutic target for cancer

Genomics - Short tandem repeat analysis monitors chimerism following bone marrow transplant

Graft-Versus-Host Disease - Denileukin diftitox tolerable and active in steroid-refractory acute GVHD

Graft-Versus-Host Disease - Donor CD8+ T cell-mediated TAA-specific antitumor response driven by GVHD

HIV/AIDS Immunology - CD25+/CD4+ cells associated with favorable clinical markers of HIV status

HIV/AIDS Immunology - Immune activation set point is established early in HIV infection

HIV/AIDS Research - APOBEC3F properties/hypermutation preferences indicate activity against HIV-1

HIV/AIDS Research - Fibronectin fragments stimulate transendothelial migration of HIV-1-infected MNL

HIV/AIDS Research - HIV-1 and MLV Gag sufficient to recruit APOBEC3G into virus-like particles

HIV/AIDS Research - HIV-1 gp120 decreases NO-dependent cyclic GMP accumulation in brain astroglia

HIV/AIDS Research - LAMPS of M. fermentans/M. penetrans activate HIV LTR through Toll-like receptors

HIV/AIDS Research - Mutations alter capsid protein assembly rate without changing monomer stability

HIV/AIDS Screening - Biotech receives U.S. FDA approval for HIV test with finger stick whole blood

HIV/AIDS Therapy - Drug-resistant HIV mutants higher in PBMC than plasma after changes in ART

HIV/AIDS Therapy - HIV phenotypic/genotypic markers of resistance evaluated at virologic failure

HIV/AIDS Therapy - New HIV technologies alter the nature of HIV medicine materially and socially

HIV/AIDS Therapy - Novel anti-HIV drug candidate targets CD4 lymphocytes

HIV/AIDS Therapy - Race is not associated with pharmacokinetics of nevirapine

HIV/AIDS Therapy - d4T treatment enhances mitochondrial oxidative stress

HIV/AIDS-Associated Infection - CD8+ T cells specific for EBV/CMV/FLU activated during primary HIV infection

Head and Neck Cancer - Fixing anemia doesn't improve survival for head and neck cancer patients

Helicobacter Pylori -  H. pylori RpoB polymorphism correlates with differential induction of IL-8

Helicobacter Pylori -  Helicobacter pylori virulence genes are associated with peptic ulcer disease

Hematology - High molecular weight hydroxyethyl starch solution stimulates platelets

Hematopoiesis - Hematopoietic cells and osteoblasts derived from common BM progenitor cell

Herpesvirus - vGPCR target gene expression drastically curtailed by host shutoff

Hormone Replacement Therapy - Estrogen plus progestin associated with increased risk of venous thrombosis

Hormone Replacement Therapy - Perioperative HRT not a risk factor for thrombosis after hip and knee surgery

Hormone Replacement Therapy - Study shows hormone pills linked to blood clots in the legs and lungs

Human T Cell Leukemia Virus - Expression of CCL5/RANTES elevated in adult T-cell leukemia cells

Hypertension - Nurses group addresses national health crisis: Uncontrolled high blood pressure

Imaging - Research at Beth Israel Deaconess broadens application of multidetector CT

Immunology - Natural toxin induces preferential and prolonged deletion of innate-like B cells

Immunology - Washington state cord blood program announces hospital partner

Immunology - vIRF3 regulates immune system and apoptosis via NF-kappaB activity inhibition

Legal Issues - Court rules that kidney failure is a disability

Legal Issues - U.S. Appeals Court overturns lower court on HDL testing infringement

Leptospirosis - Dominant leptospire genotype associated with outbreak clusters in India

Leukemia - $5 million grant targets leukemia drug development, creates new jobs

Leukemia Therapy - High-dose cytosine arabinoside/etoposide + TBI feasible in HSCT for ALL

Listeria Outbreak -  L. monocytogenes infectivity in farm animals may be associated with subtypes

Liver Cancer - Liver cirrhosis prognosis determined after first hepatic encephalopathy episode

Lung Cancer - Myotubularin-related protein suppresses growth of lung carcinoma cells

Lymphoma - Lymphoma risk does not rise with chronic exposure to 50 Hz magnetic fields

Mesothelioma - High proportion of mesothelioma in South Africa from asbestos exposure

Microbial Resistance - Fluoroquinolone use predicts rates of resistant Pseudomonas aeruginosa

Multiple Myeloma - sNDA submitted for Velcade as second-line treatment in multiple myeloma

Mycobacterium - Elevation of MAC variants to Mycobacterium chimaera sp. nov is proposed

Mycobacterium Infection - Macrolide-containing regimens 55% successful in MAC lung disease

Myocardial Infarction - Patients who get blood transfusions in hospital have higher mortality

Neutropenia - G-CSF does not improve morbidity/mortality in febrile neutropenia

Norovirus - Ethanol and bleach insufficiently inactivate norovirus model

Noscomial Infection - Hospital-acquired C. difficile infection 1300-fold higher than in community

Oncology Research - Constant light exposure increases cancer incidence and decreases lifespan

Parasitic Infection - Furamidine analog markedly potentiates activity against T. cruzi/L. amazonensis

Parasitic Infection - Smoker airflow obstruction severity correlates with Pneumocystis colonization

Parasitic Infection - ap65 gene silencing reduces vaginal epithelial cells adherence by T. vaginalis

Pediatric Pneumonia - Oral amoxicillin/parenteral penicillin equal in children with severe pneumonia

Product Licensing - FibroGen to license erythropoietic small molecule in development for anemia

Product Licensing - License application submitted for HIV-1 and hepatitis C, B screening assay

Prostate Cancer - Genomic difference found in prostate cancers between Japan and Western countries

Prostate Cancer - Neuroendocrine differentiation evaluation recommended in prostate cancer

Protozoal Disease - cAMP signaling in kinetoplastid protozoa useful target for antiparasitic drugs

Quality Assurance - Health experts support partnership for improved prevention, care of DVT

Renal Transplantation - Pharmacologic responses to methylprednisolone differ by sex

Retrovirus Research - TRIM5 alpha mediates postentry block to N-tropic murine leukemia viruses

Stem Cell Research - Advances in stem cell therapy for diabetes, new patent filing announced

Stem Cell Research - CD56-expressing cells appear to contain multipotential stem cells

Stem Cell Research - Gene expression profiles analyzed during CD4+ T cell differentiation

Stem Cell Research - Lung side population cells are derived from the bone marrow

Stem Cell Research - PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny

Stem Cell Research - TGF-beta 1 stimulates matrix metalloproteinase production by corneal cells

Stem Cell Research - Transplanted CNS cells survive/migrate/differentiate in ischemic cerebral cortex

Stem Cell Transplantation - Allogeneic HSCT induces remission of severe and refractory rheumatoid arthritis

Stem Cell Transplantation - Early CNS complications follow reduced-intensity stem cell transplantation

Stem Cell Transplantation - Stem-cell transplants may be used to repair peripheral nervous system

Stomach Cancer - Protein kinase C theta may be novel therapeutic target for GI stromal tumors

Tissue Engineering - Chondrocyte expansion on matrix monolayers does not prevent dedifferentiation

Tissue Storage - CordLife opens second tissue processing and storage facility in Singapore

Transplant Medicine - Georgia congressman has lung transplant surgery

Tumor Suppressor Gene - TES is the best candidate tumor suppressor gene at chromosome arm 7q31

Vector-Borne Pathogens - Concurrent infections with vector-borne pathogens caused fatal hemolytic anemia

Virology - JC virus genotypes 3 and 7 identified in South African patients

Virology - RNA viruses alter vector host range, resulting in potential disease emergence

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