Stem Cell Research
Lung side population cells are derived from the bone marrow
Published in Blood Weekly, October 28th, 2004
"Side population (SP) cells, a rare cell type identified by their ability to efflux the vital dye Hoechst 33342, are highly enriched for stem cell activity.
"Bone marrow (BM) SP cells uniformly express the panhematopoietic marker CD45, whereas tissue SP cells are heterogeneous in CD45 expression. In previous studies, we found that CD45 is expressed on 75% of lung SP cells," researchers in the United States report.
"By performing whole BM transplantations," wrote R. Summer and coworkers, "we determined that CD45-positive and CD45-negative lung SP cells are marrow derived....
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Source: Blood Weekly (2004-10-28)
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