Published in Blood Weekly, November 4th, 2004
According to recent research from Germany, "Internal tandem duplications (ITDs) of the juxtamembrane region of the FLT3 tyrosine kinase receptor are the most frequent genetic alterations in acute myeloid leukemia (AML). The presence of this mutation has been recognized as an independent poor prognostic factor."
"In this study," J. Tiesmeier and colleagues wrote, "we compared the FLT3 mutational status between diagnosis and subsequent relapses in 31 patients with AML. At diagnosis, 7 patients were identified to contain FLT3-ITD mutations...
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