Hematopoiesis
Leukemia-associated Rho GEF factor helps regulate early hematopoiesis stages
Published in Blood Weekly, November 4th, 2004
According to published research from Russia, "Guanine nucleotide exchange factors (GEFs) of the Dbl family activate Rho proteins and thereby participate in diverse signaling pathways involving this family of small GTPases. However, specific role of Dbl-GEFs in developmental processes, particularly cell differentiation, remains largely unexplored.
"Recently, a novel member of the Dbl family, leukemia-associated Rho GEF factor (LARG), has been reported to be a fusion partner with mixed-lineage leukemia (MLL) protein in the acute myeloid leukemia, suggesting...
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Source: Blood Weekly (2004-11-04)
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